TABLE 3.
Linearity of TTs and CQAs from C. asiatica in blank human plasma and urine.
| Analyte | Average peak area (R2) | Average area ratio (R2) | Internal standard | ||
|---|---|---|---|---|---|
| Plasma | Urine | Plasma | Urine | Plasma | |
| AA | 0.94 | 0.99 | 0.95 | 0.99 | Chrysin |
| AS | 0.82 | 0.92 | 0.75 | 0.99 | Chrysin |
| CA | 0.99 | 0.99 | 0.99 | 0.92 | FA13 |
| DHCA | 0.82 | 0.99 | 0.82 | 0.99 | FA13 |
| DHFA | 0.99 | 0.96 | 0.99 | 0.96 | DHIFAd3 |
| Di-CQAs a | 0.91 | 0.99 | 0.89 | 0.99 | FA13 |
| FA | 0.99 | 0.99 | 0.99 | 0.99 | FA13 |
| HPP | 0.99 | 0.99 | 0.99 | 0.99 | FA13 |
| IFA | 0.99 | 0.99 | 0.99 | 0.99 | IFAd3 |
| MA | 0.99 | 0.98 | 0.96 | 0.99 | Chrysin |
| Mono-CQAs b | 0.60 | 0.92 | 0.56 | 0.92 | FA13 |
| MS | 0.94 | 0.98 | 0.82 | 0.98 | Chrysin |
C. asiatica triterpene and caffeoylquinic acid analytes prepared in charcoal treated blank human plasma and blank human urine from humans following a low phytochemical diet for 48-h prior to collection. AA, asiatic acid; AS, asiaticoside; CA, caffeic acid; DHCA, dihydrocaffeic acid; DHFA, dihydroferulic acid; FA, ferulic acid; HPP, 3-(3-hydroxyphenyl)propionic acid; IFA, isoferulic acid; MA, madecassic acid; MS, madecassoside; FA13 = ferulic acid-13C3; DHIFAd3 = dihydroisoferulic acidd3; IFAd3 = isoferulic acid-d3.
Total di-caffeoylquinic acids [1,3-dicaffeoylquinic acid (1,3-diCQA), 1,4-dicaffeoylquinic acid (1,4-diCQA), 1,5-dicaffeoylquinic acid (1,5-diCQA), isochlorogenic acid A (IsoA), isochlorogenic acid B (IsoB), isochlorogenic acid C (IsoC)].
Total mono-caffeoylquinic acids [chlorogenic acid (CHLA), cryptochlorogenic acid (Crypto), neochlorogenic acid (Neo)].