Table 1.
Clinical features, treatment histories, and survival data
| Case | Age (years) | Sex | Tumor location | Resection | Tumor type at diagnosis or per WHO CNS 5 | Chemoradiation | Maintenance Temozolomide | TMZ end to recurrence (days) | Overall survival and (survival from recurrence) |
|---|---|---|---|---|---|---|---|---|---|
| pTMZ-01 | 14 | M | Left temporal | Biopsy | Infiltrating anaplastic astrocytoma with areas of PNET-like dedifferentiation |
5940 cGy TMZ 90 mg/m2 daily for 42 days |
10 cycles 150–200 mg/m2 daily for 5 days |
114 | 814 (245) |
| pTMZ-02 | 16 | M | Left parietal | Gross total | Anaplastic oligoastrocytoma |
5940 cGy TMZ 90 mg/m2 daily for 42 days |
15 cycles 200 mg/m2 daily for 5 days | 2306 | 3584 (740) |
| pTMZ-03 | 12 | M | Right frontotemporal | Gross total | Diffuse pediatric-type high-grade glioma, H3/IDH-wildtype |
6000 cGy TMZ 90 mg/m2 daily for 42 days |
17 cycles 150 mg/m2 daily for 5 days | 0 [progressed on maintenance therapy] | 1044 (406) |
| pTMZ-04 | 12 | F | Right frontal | Gross total | Diffuse pediatric-type high-grade glioma, H3/IDH-wildtype |
6000 cGy TMZ 160 mg daily for 42 days |
18 cycles 200 mg/m2 daily for 5 days | 905 | 1839 (293) |
| pTMZ-05 | 6 | M | Right cingulate | Gross total | Anaplastic astrocytoma |
5940 cGy TMZ 90 mg/m2 daily for 42 days |
18 cycles 90 mg/m2 daily for 5 days | 744 | 1639 (255) |
| pTMZ-06 | 11 | M | Right frontotemporal | Biopsy | Anaplastic astrocytoma |
Radiation details not available TMZ 100 mg daily for 42 days |
1300 mg/cycle Number of cycles not available |
397 | 892 (132) |
| pTMZ-07 | 16 | F | Left frontal | Gross total | Diffuse hemispheric glioma, H3 G34-mutant |
6000 cGy TMZ 90 mg/m2 daily for 42 days |
18 cycles 200 mg/m2 daily for 5 days |
473 | 1433 (376) |
| pTMZ-08 | 13 | M | Pineal region | Gross total | Atypical mixed glioneuronal neoplasm with aggressive features, arising in a background of papillary glioneuronal tumor |
5940 cGy TMZ 90 mg/m2 daily for 21 days |
3 cycles 200 mg/m2 daily for 5 days |
0 [progressed on maintenance therapy] | 473 (275) |
| pTMZ-09 | 8 | M | Right temporal | Subtotal | Glioblastoma | Chemoradiation details not available |
12 cycles 1300 mg/cycle |
183 | 1086 (419) |
| pTMZ-10 | 11 | M | Right temporal | Gross total | Anaplastic astrocytoma |
5940 cGy TMZ 120 mg daily for 28 days |
None | 315 | 728 (657) |
| pTMZ-11 | 17 | F | Right cerebellum | Subtotal | Astrocytoma, IDH-mutant, CNS WHO grade 4 |
5940 cGy TMZ 160 mg daily for 41 days |
Maintenance details not available | 894 | 2094 (628) |