TABLE 3:
Comparison of MRI Features at Baseline and After Acute Intervention in 11 Patients With IIH
| MRI Feature | Baseline | After Acute Interventiona | p b |
|---|---|---|---|
|
| |||
| Pituitary height (mm) | 2.4 (1.9–3.1) | 2.3 (1.7–3.6) | .50 |
| Ventricular volume (mm3) | 13,958 (8194–17,161) | 12,270 (8036–15,340) | .83 |
| Stiffness pattern score | 0.22 (0.17–0.26) | 0.25 (0.17–0.32) | .49 |
| Regional stiffness (kPa)b | |||
| Frontal lobe | 2.94 (2.91–3.14) | 2.98 (2.86–3.15) | .97 |
| Occipital lobe | 3.13 (2.98–3.34) | 3.24 (2.95–3.43) | .73 |
| Parietal lobe | 2.89 (2.83–3.04) | 2.93 (2.86–3.08) | > .99 |
| Temporal lobe | 3.17 (3.03–3.26) | 3.10 (3.03–3.32) | > .99 |
| GMWM junction | 3.36 (3.21–3.57) | 3.37 (3.32–3.62) | .70 |
| Corpus callosum | 2.85 (2.64–3.07) | 2.92 (2.77–3.17) | .96 |
| Cerebellum | 2.04 (1.98–2.09) | 2.08 (2.03–2.19) | .93 |
| Brainstem | 3.80 (3.59–4.23) | 3.74 (3.33–4.22) | > .99 |
| Global regionc | 2.96 (2.85–3.04) | 2.95 (2.88–3.14) | .97 |
| Transverse sinus stenosisd | 88 (7/8) | 88 (7/8) | — |
| Inferior cerebellar tonsillar descent | 9 (1/11) | 9 (1/11) | — |
Note—Data are reported as median with IQR in parentheses or as percentage with numerator and denominator in parentheses. Dash (—) indicates not calculated. IIH = idiopathic intracranial hypertension, GMWM = gray matter–white matter.
a
Large-volume diagnostic lumbar puncture.
b
Calculated using the Wilcoxon signed rank test. Values for regional stiffness were corrected for the false-discovery rate.
c
Includes all eight regions.
d
The denominator is less than the total number of patients in a given group due to the lack of MR venography sequence in the MRI examinations of some patients.