TABLE 4:
Comparison of MRI Features at Baseline and After Chronic Intervention in 12 Patients With IIH
| MRI Feature | Baseline | After Chronic Interventiona | p b |
|---|---|---|---|
|
| |||
| Pituitary height (mm) | 3.2 (2.5–3.5) | 4.0 (2.5–4.6) | .05 |
| Ventricular volume (mm3) | 14,840 (13,489–19,765) | 15,119 (13,602–19,549) | .97 |
| Stiffness pattern score | 0.25 (0.20–0.34) | 0.23 (0.19–0.28) | .11 |
| Regional stiffness (kPa) | |||
| Frontal lobe | 3.04 (2.90–3.11) | 3.02 (2.96–3.20) | .46 |
| Occipital lobe | 3.03 (2.96–3.28) | 3.10 (3.00–3.22) | .83 |
| Parietal lobe | 2.89 (2.76–2.99) | 2.85 (2.79–2.98) | > .99 |
| Temporal lobe | 3.09 (3.00–3.17) | 3.05 (2.99–3.17) | > .99 |
| GMWM junction | 3.41 (3.27–3.62) | 3.30 (3.26–3.48) | .52 |
| Corpus callosum | 2.85 (2.66–3.02) | 2.90 (2.65–3.18) | .87 |
| Cerebellum | 1.98 (1.92–2.03) | 2.05 (1.96–2.08) | .68 |
| Brainstem | 3.65 (3.35–4.01) | 3.76 (3.31–4.24) | .87 |
| Global regionc | 2.91 (2.82–3.02) | 2.95 (2.82–3.02) | .51 |
| Transverse sinus stenosisd | 100 (11/11) | 36 (4/11) | — |
| Inferior cerebellar tonsillar descent | 17 (2/12) | 17 (2/12) | — |
Note—Data are reported as median with IQR in parentheses or as percentage with numerator and denominator in parentheses. Dash (—) indicates not calculated. IIH = idiopathic intracranial hypertension, GMWM = gray matter–white matter.
a
Medical management or venous sinus stenting.
b
Calculated using the Wilcoxon signed rank test. Values for regional stiffness were corrected for the false-discovery rate.
c
Includes all eight regions.
d
The denominator is less than the total number of patients in a given group due to the lack of MR venography sequence in the MRI examinations of some patients.