Figure EV2. Additional genomic changes associated with the Sb^III‐Flash selection performed on the barcoded BPK282 population.

1. Heatmap depicting the allele frequencies of SNPs and indels identified in protein coding regions compared to the reference genome. An additional annotation bar display to which group (control or Sb^III‐exposed) a sample belongs. Samples are named as Px_cPOPy for controls, and Px_SePOPy for the Sb^III‐exposed groups, with x being the number of passages and y being the replicate number. The initial population is named as ‘Before Sb^III’.
2. Copy number variation in the MRPA locus. The Y axis represents the median read count of 5 kb bins normalized by the median count of chromosome 23 and reflects the average copy number per haploid genome of the MRPA locus.