FIGURE 1.

Consort diagram. Patients entering a W&W program or who “refused surgery” according to the case record forms were grouped together since the predominant reason for the refusers was no remaining tumor/no need for surgery. These patients were included in the LRR analysis. The 2 patients who initially entered a W&W strategy/refused surgery but later developed regrowth without having surgery were scored as LRR. When W&W patients with tumor regrowth underwent a curative resection, this was not scored as LRR. However, when regrowth was subsequent to a radical resection in W&W patients, this was scored as LRR. F-UP indicates follow-up; IC, informed consent; PD progressive disease.