TABLE 2.
Quality of life – QLQ-C30 (version 3.0)
| Marchegiani et al37 | Stoop et al36 | Overall | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stratum 1 | Stratum 2 | Stratum 3 | P-value | Clinical significance29 | |||||||||
| TP (n=33) | PD (n=62) | TP (n=13) | PD (n=5) | TP (n=16) | PD (n=18) | TP (n=10) | PD (n=20) | TP (n=72) | PD (n=105) | Δ | |||
| Global health status | 79 (15) | 78 (19) | 76 (12) | 67 (20) | 73 (15) | 74 (26) | 77 (16) | 77 (17) | 77 (15) | 76 (20) | 0.857 | + 0.5 | No change |
| Functioning | |||||||||||||
| Physical functioning | 88 (12) | 85 (20) | 79 (23) | 77 (14) | 76 (11) | 81 (20) | 81 (14) | 86 (22) | 83 (15) | 84 (20) | 0.584 | − 1.5 | No change |
| Role functioning | 86 (20) | 85 (25) | 69 (29) | 77 (22) | 77 (22) | 72 (32) | 75 (26) | 83 (24) | 80 (23) | 82 (26) | 0.552 | − 2.3 | No change |
| Emotional functioning | 82 (20) | 80 (22) | 91 (9) | 77 (18) | 88 (17) | 82 (21) | 89 (13) | 87 (20) | 86 (17) | 82 (21) | 0.160 | + 4.2 | No change |
| Cognitive functioning | 90 (13) | 86 (20) | 88 (13) | 97 (7) | 79 (16) | 82 (18) | 83 (26) | 89 (22) | 87 (15) | 87 (19) | 0.971 | − 0.1 | No change |
| Social functioning | 88 (18) | 85 (25) | 64 (22) | 80 (30) | 75 (24) | 70 (35) | 82 (28) | 87 (18) | 80 (22) | 83 (26) | 0.424 | − 3.0 | No change |
| Symptoms | |||||||||||||
| Fatigue | 16 (19) | 19 (23) | 30 (28) | 24 (9) | 39 (15) | 30 (31) | 32 (15) | 25 (21) | 26 (20) | 22 (24) | 0.255 | + 3.9 | No change |
| Nausea & vomiting | 5 (14) | 4 (9) | 5 (11) | 13 (22) | 8 (18) | 13 (32) | 5 (11) | 11 (17) | 6 (14) | 7 (17) | 0.439 | − 1.9 | No change |
| Pain | 12 (19) | 8 (17) | 14 (23) | 13 (14) | 22 (19) | 24 (31) | 15 (21) | 19 (22) | 15 (20) | 13 (21) | 0.605 | + 1.6 | No change |
| Dyspnoea | 4 (14) | 6 (17) | 23 (32) | 40 (28) | 23 (20) | 24 (23)* | 27 (27) | 12 (16) | 15 (21) | 12 (18) | 0.324 | + 3.0 | No change |
| Insomnia | 30 (29) | 22 (30) | 23 (29) | 13 (18) | 31 (33) | 15 ((23) | 33 (42) | 12 (20) | 30 (32) | 18 (27) | 0.012 | + 11.2 | Moderate change |
| Appetite loss | 5 (12) | 9 (20) | 0 (0) | 13 (18) | 6 (13) | 13 (28) | 7 (21) | 16 (28)* | 5 (13) | 11 (23) | 0.038 | − 6.3 | Little change |
| Constipation | 5 (12) | 9 (21) | 0 (0) | 20 (30) | 4 (11) | 13 (28) | 10 (23) | 15 (23) | 5 (13) | 11 (23) | 0.025 | − 6.8 | Little change |
| Diarrhoea | 18 (26) | 24 (28) | 38 (33) | 13 (18) | 31 (33) | 22 (30) | 30 (33) | 18 (23) | 26 (30) | 22 (27) | 0.338 | + 4.2 | No change |
| Financial difficulties | 10 (21) | 10 (22) | 5 (13) | 0 (0) | 15 (27) | 9 (25) | 0 (0) | 12 (27) | 9 (20) | 9 (23) | 0.761 | −1.0 | No change |
Bold values are statistically significant.
All values are on a scale from 0 to 100%, expressed in means with standard deviation (SD), unless expressed differently. High scores of global health status and functioning indicate good quality of life, whereas high symptom scores suggest poor quality of life.
*
n=1 missing data.
PD indicates pancreatoduodenectomy; TP, total pancreatectomy.