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. 2023 Aug 23;10:1201007. doi: 10.3389/fnut.2023.1201007

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Copyright © 2023 Janilkarn-Urena, Idrissova, Zhang, VanDreal, Sanghavi, Skinner, Cheng, Zhang, Watanabe, Asatryan, Cadenas and Davies.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DHM increases ethanol-induced colocalization events between p62/SQSTM-1 and perilipin 1 (PLIN-1). Confocal images (scale bars 5 μm) from the livers of mice receiving the LDC diet confirm the presence and interaction between p62/SQSTM-1 and perilipin 1 (PLIN-1). As shown: p62/SQSTM-1 (green), perilipin 1 (red), and nuclei (blue). Colocalization events are circled between p62/SQSTM-1 + PLIN-1 (yellow/brown). The magnified image from the DHM group highlights the nuclei (blue), p62/SQSTM-1 (green), and PLIN-1 (red) and the magnitude and distribution of colocalization events on lipid droplets.