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. 2023 Aug 23;14:1213891. doi: 10.3389/fphar.2023.1213891

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Copyright © 2023 Li, Li, Xu, Li, Hu, Li, Yu, Wang and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The genetic alteration and DNA methylation profile of SERPINE1 in pan-cancer. (A) The genetic alteration condition of SERPINE1 among cancers based on cBioPortal database. (B) The composition of SERPINE1 mutation in pan-cancer according to cBioPortal database. (C) The composition of SERPINE1 copy number variation according to GSCA database. d_total, total copy number deletion percentage; d_homo, homozygous copy number deletion percentage; d_hete, heterozygous copy number deletion percentage; a_total, total copy number amplification percentages percentage; a_homo, homozygous copy number amplification percentage; a_hete, heterozygous copy number amplification percentage. (D) Spearman’s rank correlations of SERPINE1 expression with the DNA methylation level and copy number variance.