Table 2.

Associations of independent genetic variants with relative slope of eGFR

Variant Characteristics						Cross-Ancestry Analysis					White Participants					Black Participants
Identifier	Nearest Gene	Chr	Position	EA	OA	EAF		β	SEM	P	EAF		β	SEM	P	EAF	β	SEM		P
Overall
rs77924615	UMOD-PDILT	16	20392332	G	A	0.80		−0.30	0.03	4.9×10−27	0.78		−0.30	0.03	7.2×10−27	0.81	−0.20		0.20		0.32
rs11592748	BICC1	10	60284915	A	G	0.57		0.13	0.02	5.6×10−9	0.55		0.13	0.02	2.4×10−8	0.24	0.21		0.10		0.07
rs16996674	APOL1/MYH9	22	36726652	T	C	0.26		−0.57	0.10	2.1×10−8	0.00		—	—	—	0.26	−0.57		0.10		2.1×10−8
Participants with diabetes
rs77924615	UMOD-PDILT	16	20392332	G	A	0.80		−0.45	0.06	2.2×10−13	0.80		−0.46	0.06	1.5×10−13	0.94	−0.10		0.40		0.81
rs11624911	HEATR4	14	74026568	A	C	0.18		0.02	0.06	0.75	0.20		−0.02	0.06	0.69	0.03	0.29		0.05		1.3×10−8
Participants without diabetes
rs36060036	UMOD-PDILT	16	20361950	T	C	0.16		0.27	0.03	1.9×10−17	0.16		0.27	0.03	2.4×10−18	0.07	0.32		0.21		0.12
rs11592748	BICC1	10	60284915	A	G	0.57		0.14	0.02	6.7×10−9	0.56		0.14	0.03	3.0×10−8	0.78	0.25		0.13		0.06

β from a linear mixed model of genetic variant dosage on repeated log-transformed eGFR measurements, adjusted for age, sex, and first ten principal components of ancestry, stratified by ethnicity and diabetes, and then meta-analyzed for overall cross-ancestry results. EA, effect allele; OA, other allele; EAF, effect allele frequency; β, regression estimate, difference in % decline/yr per additional copy of the effect allele; SEM, standard error of the mean.