Figure 1.
Overall survival and other markers of excretory kidney function; albuminuria and other markers of kidney barrier function. (A) Percentage reaching primary end point (overall survival) of WT, CKD-veh, CKD-RASi, CKD-RASi/SGLT2i, and CKD-RASi/SGLT2i/MRA groups. (B) Effects of RASi, RASi/SGLT2i, and RASi/SGLT2i/MRA treatments on GFR. (C) Body weight changes after 6 weeks (shown as a percentage of initial body weight). (D) The progression of proteinuria from 6 to 8.5 weeks. (E) The level of BUN and serum creatinine at 8.5 weeks. WT, wild type; RASi, renin-angiotensin-system inhibitor; SGLT2i, Sodium-glucose-transporter-2 inhibitor; MRA, mineralocorticoid receptor antagonist.