Table 3.
Measures of nephron size as predictors of progressive CKD from 4 months after a radical nephrectomy
| Predictor (per SD) | Unadjusted | Glomerular Volume and Proximal Tubular Diameter (Model 2) | Glomerular Volume and Distal Tubular Diameter (Model 3) | Model 3 Further Adjusted for Clinical Characteristicsa | ||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Superficial depth | ||||||||
| Glomerular volume | 1.73 (1.50 to 1.99) | <0.0001 | 1.64 (1.36 to 1.97) | <0.0001 | 1.37 (1.15 to 1.64) | 0.0005 | 1.23 (0.99 to 1.54) | 0.07 |
| Proximal tubular diameter | 1.63 (1.30 to 2.04) | <0.0001 | 1.14 (0.86 to 1.51) | 0.36 | — | — | — | — |
| Distal tubular diameter | 2.25 (1.83 to 2.78) | <0.0001 | — | — | 1.87 (1.46 to 2.38) | <0.0001 | 1.81 (1.40 to 2.35) | <0.0001 |
| Middle depth | ||||||||
| Glomerular volume | 1.75 (1.52 to 2.02) | <0.0001 | 1.94 (1.58 to 2.38) | <0.0001 | 1.53 (1.29 to 1.83) | <0.0001 | 1.51 (1.19 to 1.92) | 0.0007 |
| Proximal tubular diameter | 1.31 (1.04 to 1.66) | 0.02 | 0.80 (0.59 to 1.10) | 0.17 | — | — | — | — |
| Distal tubular diameter | 1.82 (1.48 to 2.24) | <0.0001 | — | — | 1.44 (1.13 to 1.85) | 0.004 | 1.34 (1.03 to 1.74) | 0.03 |
| Deep depth | ||||||||
| Glomerular volume | 1.75 (1.51 to 2.02) | <0.0001 | 1.68 (1.40 to 2.02) | <0.0001 | 1.65 (1.40 to 1.96) | <0.0001 | 1.46 (1.22 to 1.76) | <0.0001 |
| Proximal tubular diameter | 1.54 (1.23 to 1.94) | 0.0002 | 1.11 (0.84 to 1.46) | 0.46 | — | — | — | — |
| Distal tubular diameter | 1.60 (1.25 to 2.04) | 0.0002 | — | — | 1.21 (0.92 to 1.58) | 0.17 | 1.18 (0.89 to 1.56) | 0.26 |
There were 62 events. HR, hazard ratio; CI, confidence interval.
a
Adjusted for age, sex, BMI, hypertension, diabetes, postnephrectomy baseline eGFR, and proteinuria.