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. Author manuscript; available in PMC: 2023 Sep 6.
Published in final edited form as: Acta Neuropathol. 2022 Aug 18;144(4):733–746. doi: 10.1007/s00401-022-02484-7

Fig. 6.

Fig. 6

Molecular and clinical characteristics of CNS-NB-FOXR2 tumors. (a) Oncoprint aligning clinical features with molecular findings. (b) Box plots for FOXR2 and SOX10 genes show higher expression (transcript per million, TPM) in CNS-NB-FOXR2 samples than in other CNS embryonal tumors (c-d) EFS and OS by treatment category. Abbreviations: CNS, central nervous system, CNS-SARC-CIC, CNS sarcoma with CIC rearrangement; CNS-SARC-DICER, CNS sarcoma with DICER mutation, CNS-NB-FOXR2, CNS neuroblastoma with FOXR2 activation; CSI, craniospinal irradiation; ETMR, embryonal tumor with multilayered rosettes; F, female; GTR, gross-total resection; HGG, high-grade glioma; HGNET, high-grade neuroepithelial tumor; HGNET-BCOR, high-grade neuroepithelial tumor with BCOR alteration; M, male; M0, non-metastatic; MNP classifier, Molecular Neuropathology brain tumor classifier; NPTP, non-protocol treatment plan; NTR, near-total resection; PNET, primitive neuro-ectodermal tumor; RT, radiation therapy; STR, subtotal resection; TSNE, t-stochastic neighbor embedding.