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. 2023 Aug 23;14:1191757. doi: 10.3389/fimmu.2023.1191757

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Copyright © 2023 Huang, Wu, Wu, Huang and Shen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Chest CT showing enlarged mediastinal lymph nodes (yellow arrow) and PET/CT with hypermetabolic mediastinal lymph nodes (red arrow). (B)Pedigree chart of the patient. (C) Trends in red blood cells (RBC), white blood cells (WBC), platelet count (PLT) levels and treatments during the patient’s hospital stay. (D) Changes in ferritin (Fer) and lactate dehydrogenase (LDH) during the hospitalization. (E) GATA2 variants sites of two GATA2 deficiency-related HLH patients in our center (Protter, http://wlab.ethz.ch/protter). Heatmap (F) and volcano plot (G) for differentially expressed genes identified comparing patient and healthy controls (HCs) (volcano plot was performed using the OmicStudio tools at https://www.omicstudio.cn). (H) The comparisons of plasma levels of inflammatory cytokines between the patient and HCs. **P ≤ 0.01; *P ≤ 0.05.