Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 23;14:1243689. doi: 10.3389/fimmu.2023.1243689

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 An, Baghela, Zhang, Blimkie, Gauthier, Kaufmann, Acton, Lee, Levesque and Hancock

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

At follow-up, the Resolved (RS) and Unresolved (UR) endotypes had multiple oppositely regulated underlying mechanisms. Shown are a subset of the enriched Reactome pathways, with all enriched pathways in Figure S3E . On the left, each endotype is compared to the rest of the follow-up samples not in that endotype (e.g., RS compared to Suppressive/SP and UR). On the right, each endotype is compared to another endotype, indicating that the SP endotype patients had cellular function changes like UR and immune changes like RS. The direction of arrows indicates whether the pathway was up- or down-regulated. The total number of DE genes are displayed under each comparison.