Table II.

Risk factors for disseminated coccidioidomycosis.^{1,6,10,12,20,34,35,55–57}

Older Age	Primary Immunodeficiency
Male Gender	Hyper IgE syndrome (STAT3 mutations)
Pregnancy	IFN-γR1 polymorphisms
Black race and Filipino ancestry	IL12-Rβ1 or IL12-Rβ2 mutations
	STAT1 gain of function polymorphisms
Immunosuppression	Other suspected deleterious genetic lesions
HIV	Innate immune sensing*
Cancer/Chemotherapy	Signaling from innate sensing*
Solid Organ Transplantation	NFkB signaling*
Anti-inflammatory biological medications	IL-17 signaling*,**
	Human chitinase (CHIT1)**

^*Reference Hardison and Brown.³⁶

^**This report.