Table 3.

The inhibitor/substrate features of compounds 1a-1i at CYP2D6, CYP3A4, CYP1a2, CYP2C19, and CYP2C9.

Compounds	CYP3A4 substrate/inhibitors	CYP2C9 substrate/inhibitors	CYP2D6 substrate/inhibitors	CYP2C19 inhibition	CYP1a2 inhibition
1a	yes/no	no/yes	no/no	yes	yes
1b	yes/no	no/yes	no/no	yes	yes
1c	yes/no	no/yes	no/no	yes	yes
1d	yes/no	no/no	no/no	yes	yes
1e	yes/no	no/yes	no/no	yes	yes
1f	yes/no	no/yes	no/no	yes	yes
1g	yes/no	no/yes	no/no	yes	yes
1h	no/no	no/no	no/no	no	yes
1i	yes/yes	no/yes	no/no	yes	yes