3D structure of tumor spheroid with low and high uniformities and the related statistics of dynamic changes of tumor spheroid volumes. A, 3D structures of tumor tissues with low and high uniformity within tumor spheroids on day 11. B, corresponding statistics of dynamic change of tumor tissue volumes over time. 2-ME, 2-Methoxyestradiol. AZD, AZD1208. R-Ke, R-Ketorolac.