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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: IEEE Trans Biomed Eng. 2023 May 19;70(6):1891–1901. doi: 10.1109/TBME.2022.3231835

Fig. 6.

Fig. 6.

3D structure mapping and distribution of dead cells within MCTs by attenuation contrast and Operetta imaging. A, 3D structures of necrotic tissues within tumor spheroids under treatments of three inhibitors. B, dynamic change of the volume of necrotic tissues. C, the relative ratio between the volume of necrotic tissues and tumor spheroids. D, the distribution image of necrotic tissues in tumor spheroids treated with inhibitors with different concentrations from OCT on day 11. Necrotic tissues were marked by red and overlayed on OCT intensity images (gray). E, the distribution of necrotic tissues in tumor spheroids treated with inhibitors with different concentrations from Operetta on day 11. Red color indicated necrotic tissues. Scale bar: 300 μm.