Extended Data Fig. 1. Major COVID-19 biological pathways mapped with susceptibility and severity GWAS loci.

Genome-wide significant variants associated with COVID-19 (white boxes) and the annotated genes (peach boxes) are mapped on to pathways known to be involved in (a) viral entry and innate immunity, (b) entry defence in airway mucus, and (c) type I interferon. The suggested phenotypic impact of the significant variants using the Bayesian approach² are denoted with shapes; COVID-19 susceptibility (pink circles), COVID-19 disease severity (green triangles), and unclassified variants (blue cross). Other genes known to be involved in the aforementioned pathways are shown using grey boxes. Detailed list of references to studies used to design this pathway can be found in Supplementary Note.