Table 3.
Comparison between serious and non-serious reactions
| Serious reactions | Non-serious reactions | OR (95% CI) | p value | |
|---|---|---|---|---|
| N | 318 | 12 | ||
| Neonatal sex: Females, n (%) | 115 (36.2)a | 4 (33.3)b | 1.00 (0.20–4.31) | 1.00 |
| Neonatal age (days), median (Q1–Q3) | 1.0 (0.0–1.0) | 1.0 (0.0–1.3) | NA | 0.93 |
| Maternal DDD, median (Q1–Q3) | 1.0 (1.0–2.0)c | 1.0 (0.4–1.8)d | NA | 0.49 |
| Duration of the maternal antidepressant treatment (days), median (Q1–Q3) | 258.0 (222.0–271.8)e | 85.0 (83.5–86.5)f | NA | 0.08 |
| Duration of neonatal withdrawal syndrome (days), median (Q1–Q3)d | 7.0 (3.0 11.0)g | 2.5 (1.0–5.5)h | NA | 0.18 |
| With mood stabilizers (n) | 32 | 1 | 1.23 (0.17–54.61) | 1.00 |
| With benzodiazepines (n) | 99 | 2 | 2.26 (0.47–21.55) | 0.36 |
| With other antidepressants (n) | 41 | 1 | 1.63 (0.23–71.75) | 1.00 |
| With antipsychotics (n) | 78 | 2 | 1.62 (0.33–15.55) | 0.74 |
| With opioids (n) | 43 | 1 | 1.72 (0.24–75.71) | 1.00 |
CI, confidence interval; DDD, defined daily dose; NA, not applicable; OR, odds ratio; Q1, first quartile; Q3, third quartile.
a
Missing data for 31 neonates.
b
Missing data for two neonates.
c
Data available for 180 neonates.
d
Data available for 7 neonates.
e
Data available for 86 neonates.
f
Data available for two neonates.
g
Data available for 62 neonates.
h
Data available for four neonates.