Table 1.
Sample demographic information and affective cognition
| Control n = 784 | MDD-r n = 282 | MDD-c n = 43 | p value | |
|---|---|---|---|---|
| Demographic information | ||||
| Age (years), median (IQR)a | 62 (7.3) | 60 (10.8) | 60 (7.3) | 1.2 × 10−8 A |
| Sex female, n (%)b | 417 (53.2) | 200 (70.9) | 32 (74.4) | 1.4 × 10−7 A |
| Educationb | 0.22 | |||
| Compulsory, n (%) | 203 (25.9) | 60 (21.3) | 12 (27.9) | |
| > Compulsory, n (%) | 262 (33.4) | 111 (39.4) | 18 (41.9) | |
| Post-secondary, n (%) | 319 (40.7) | 111 (39.4) | 13 (30.2) | |
| Handednessb | 0.63 | |||
| Right, n (%) | 701 (89.4) | 250 (88.7) | 41(95.3) | |
| Left, n (%) | 56 (7.1) | 19 (6.7) | 1 (2.3) | |
| Mixed, n (%) | 27 (3.4) | 13 (4.6) | 1 (2.3) | |
| Total QIDS, median (IQR)a | 3 (2.0) | 5 (4.0) | 13 (6.0) | <2.2 × 10−16 B |
| Psychotropic medicationc, n (%)b | 38 (4.8) | 93 (33.0) | 27 (62.8) | <2.2 × 10−16 B |
| Antidepressant medication, n (%)b | 30 (3.8) | 85 (30.1) | 26 (60.5) | <2.2 × 10−16 B |
| Affective cognition | ||||
| BERT, affective bias | ||||
| N | 773 | 282 | 42 | |
| Mean (s.d.)d | 0.04 (0.24) | 0.05 (0.23) | 0.05 (0.23) | 0.86 |
| FAGN, affective bias | ||||
| N | 759 | 278 | 38 | |
| Mean (s.d.)d | −0.03 (0.08) | −0.03 (0.06) | −0.02 (0.07) | 0.65 |
| CGT, risk adjustment win | ||||
| N | 779 | 281 | 42 | |
| Mean (s.d.)d | 0.96 (1.28) | 0.93(1.29) | 0.96 (1.11) | 0.97 |
| CGT, risk adjustment loss | ||||
| N | 778 | 281 | 42 | |
| Mean (s.d.)d | 1.10 (1.29) | 1.09 (1.25) | 1.33 (1.12) | 0.51 |
BERT, Bristol Emotion Recognition Task; CGT, adapted Cambridge Gambling Task; FAGN, Face Go/No-Go; MDD-c, current major depressive disorder; MDD-r, remitted from major depressive disorder; RA, risk adjustment; QIDS, Quick Inventory of Depressive Symptomatology.
Kruskal Wallis test, if significant followed up by Dunn's test for pairwise comparisons.
Chi-squared test, if significant followed up by pairwise chi-squared tests.
Use of antidepressant, antipsychotic, anticonvulsant, anxiolytic, hypnotic and/or mood-stabilising medications.
One-way ANOVA test.
Significant differences between control and MDD-r, and between control and MDD-c.
Significant differences between all three groups.