Table 2.

Model estimated changes in primary and secondary outcomes

	CBT	LDT	TAU	CBT v. TAU	LDT v. TAU	CBT v. LDT
Slope 1: Change from baseline through midpoint- to post-intervention
Insomnia Severity Index	−7.58 (−9.01; −6.16), p < 0.001	−6.39 (−7.97; −4.81), p < 0.001	−2.73 (−3.99; −1.47), p < 0.001	−4.86 (−6.64; −3.07), p < 0.001, −2.01	−3.66 (−5.58; −1.74), p < 0.001, −1.52	−1.20 (−3.23; 0.84), p = 0.25, −0.50
PROMIS Sleep Disturbance	−12.02 (−14.18; −9.87), p < 0.001	−10.72 (−13.03; −8.41), p < 0.001	−2.69 (−4.41; −0.97), p = 0.002	−9.33 (−11.78; −6.88), p < 0.001, −1.68	−8.03 (−10.65; −5.41), p < 0.001, −1.44	−1.30 (−3.98; 1.39), p = 0.34, −0.23
Epworth Sleepiness Scale	−1.14 (−2.10; −0.18), p = 0.02	−1.01 (−1.75; −0.27), p = 0.007	−0.06 (−1.04; 0.91), p = 0.90	−1.08 (−2.38; 0.23), p = 0.11, −0.29	−0.95 (−2.20; 0.32), p = 0.14, −0.26	−0.13 (−1.30; 1.04), p = 0.82, −0.04
Karolinska Sleepiness Scale	−0.86 (−1.68; −0.03), p = 0.04	−0.80 (−1.62; 0.02), p = 0.06	−0.23 (−0.89; 0.44), p = 0.51	−0.63 (−1.33; 0.07), p = 0.08, −0.38	−0.58 (−1.27; 0.12), p = 0.10, −0.34	−0.06 (−0.82; 0.71), p = 0.89, −0.03
Fatigue Assessment Scale	−4.52 (−5.79; −3.25), p < 0.001	−2.82 (−4.22; −1.41), p < 0.001	−1.46 (−2.45; −0.46), p = 0.004	−3.07 (−4.51; −1.62), p < 0.001, −0.85	−1.36 (−3.01; 0.29), p = 0.11, −0.38	−1.71 (−3.45; 0.03), p = 0.05, −0.47
PROMIS Depression	−5.80 (−7.66; −3.94), p < 0.001	−6.35 (−9.04; −3.65), p < 0.001	−3.98 (−6.08; −1.88) p < 0.001	−1.82 (−4.57; 0.93), p = 0.20, −0.28	−2.37 (−5.63; 0.89), p = 0.16, −0.36	0.55 (−2.75; 3.84), p = 0.74, 0.08
PROMIS Anxiety	−4.39 (−6.87; −1.92), p < 0.001	−6.24 (−8.93; −3.54), p < 0.001	−3.53 (−5.99; −1.06), p = 0.005	−0.87 (−4.21; 2.48), p = 0.61, −0.12	−2.71 (−6.39; 0.97), p = 0.15, −0.36	1.84 (−1.91; 5.59), p = 0.34, 0.25
Slope 2: Change from post-intervention to follow-up
Insomnia Severity Index	−0.30 (−1.23; 0.62), p = 0.52	0.05 (−1.39; 1.49), p = 0.95	−1.34 (−2.45; −0.23), p = 0.02	1.04 (−0.40; 2.48), p = 0.16	1.39 (−0.44; 3.22), p = 0.14	−0.35 (−2.03; 1.32), p = 0.68
PROMIS Sleep Disturbance	−0.75 (−2.81; 1.32), p = 0.48	0.80 (−1.70; 3.29), p = 0.53	−3.19 (−5.18; −1.19), p = 0.002	2.44 (−0.41; 5.29), p = 0.09	3.98 (0.79; 7.17), p < 0.05	−1.54 (−4.64; 1.56), p = 0.33
Epworth Sleepiness Scale	−0.07 (−0.74; 0.61), p = 0.85	−0.25 (−0.95; 0.44), p = 0.48	−0.46 (−0.99; 0.07), p = 0.092	0.39 (−0.47; 1.25), p = 0.37	0.20 (−0.66; 1.06), p = 0.64	0.19 (−0.78; 1.15), p = 0.70
Karolinska Sleepiness Scale	−0.09 (−0.93; 0.75), p = 0.83	−0.62 (−1.54; 0.31), p = 0.19	0.09 (−0.58; 0.76), p = 0.79	−0.18 (−1.06; 0.71), p = 0.69	−0.71 (−1.71; 0.30), p = 0.17	0.53 (−0.53; 1.58), p = 0.33
Fatigue Assessment Scale	−0.21 (−0.98; 0.56), p = 0.59	−0.94 (−2.06; 0.18), p = 0.10	−0.63 (−1.24; −0.03), p = 0.04	0.42 (−0.57; 1.40), p = 0.41	−0.31 (−1.57; 0.95), p = 0.63	0.73 (−0.61; 2.07), p = 0.29
PROMIS Depression	−0.63 (−2.33; 1.07), p = 0.47	0.71 (−1.71; 3.12), p = 0.57	−0.00 (−1.79; 1.79), p > 0.99	−0.63 (−3.11; 1.86), p = 0.62	0.71 (−2.18; 3.59), p = 0.63	−1.34 (−4.29; 1.62), p = 0.38
PROMIS Anxiety	−1.56 (−3.45; 0.33), p = 0.11	0.86 (−2.31; 4.04), p = 0.59	−1.87 (−3.89; 0.14), p = 0.07	0.31 (−2.48; 3.11), p = 0.83	2.74 (−0.98; 6.45), p = 0.15	−2.42 (−6.15; 1.30), p = 0.20

CBT, cognitive behavioural therapy group; LDT, light dark therapy group; TAU, treatment-as-usual control group. Model estimated mean (95% confidence interval), p value adjusting for baseline levels and strata are displayed; for Slope 1, effect sizes were added for between group comparisons based on values at post-intervention. The first three columns show model estimated changes for each group; the remaining columns show group differences in the changes. For model estimated statistics at each time point, please see online Fig. S2 and Table S1 in the Supplementary, which also includes effect sizes.