Table 2.
Postoperative secondary outcomes compared between the FE-DALK and S-DALK groups.
| FE-DALK Mean ± SD (n) |
S-DALK Mean ± SD (n) |
Adjusted difference FE-DALK - S-DALK (95% CI) |
p-Value (Overall)a |
p-Value (Interaction)b |
|
|---|---|---|---|---|---|
| Mean postoperative astigmatism (D) | |||||
| 6 months | 7.1 ± 3.8 (28) | 7.2 ± 3.6 (23) | −0.63 (−2.80, +1.55) | 0.289 | 0.187 |
| 12 months | 7.3 ± 4.0 (24) | 5.0 ± 2.2 (19) | +1.66 (−0.68, +3.99) | ||
| 15 months | 7.5 ± 4.5 (25) | 6.3 ± 4.7 (23) | +0.78 (−1.44, +3.00) | ||
| Surgically induced astigmatism (D) | |||||
| 6 months | 12.4 ± 7.0 (16) | 7.8 ± 3.5 (13) | +2.48 (−1.46, +6.42) | 0.573 | 0.495 |
| 12 months | 9.9 ± 7.7 (20) | 8.4 ± 4.0 (16) | +1.02 (−2.75, +4.80) | ||
| 15 months | 8.8 ± 8.8 (25) | 7.9 ± 4.4 (22) | +0.89 (−2.70, +4.47) | ||
| Uncorrected visual acuity (logMAR) | |||||
| 6 months | 0.90 ± 0.33 (27) | 0.79 ± 0.27 (23) | +0.076 (−0.121, +0.274) | 0.809 | 0.940 |
| 12 months | 0.88 ± 0.41 (26) | 0.79 ± 0.31 (19) | +0.047 (−0.163, +0.258) | ||
| 15 months | 0.91 ± 0.43 (25) | 0.81 ± 0.37 (20) | +0.085 (−0.120, +0.291) | ||
| Best spectacle-corrected visual acuity (logMAR) | |||||
| 6 months | 0.54 ± 0.27 (27) | 0.43 ± 0.17 (23) | +0.042 (−0.122, +0.206) | 0.172 | 0.333 |
| 12 months | 0.56 ± 0.31 (25) | 0.41 ± 0.26 (20) | +0.120 (−0.050, +0.290) | ||
| 15 months | 0.57 ± 0.36 (25) | 0.37 ± 0.29 (22) | +0.170 (+0.003, +0.337) | ||
| Steep keratometry (D) | |||||
| 6 months | 47.7 ± 3.2 (28) | 49.4 ± 3.0 (23) | −1.77 (−3.47, −0.07) | 0.057 | 0.035 |
| 12 months | 49.0 ± 3.0 (24) | 48.3 ± 2.6 (19) | +0.42 (−1.38, +2.22) | ||
| 15 months | 48.4 ± 3.2 (25) | 48.5 ± 2.8 (23) | −0.32 (−2.05, +1.40) | ||
| Flat keratometry (D) | |||||
| 6 months | 40.6 ± 3.6 (28) | 42.2 ± 2.5 (23) | −0.99 (−3.20, +1.22) | 0.786 | 1.000 |
| 12 months | 41.8 ± 3.9 (24) | 43.2 ± 3.1 (19) | −1.00 (−3.31, +1.31) | ||
| 15 months | 40.8 ± 4.2 (25) | 42.3 ± 5.3 (23) | −0.98 (−3.22, +1.25) | ||
| Manifest sphere (D) | |||||
| 6 months | −5.9 ± 5.1 (27) | −5.5 ± 5.5 (23) | +0.59 (−2.23, +3.40) | 0.885 | 0.811 |
| 12 months | −6.6 ± 5.1 (25) | −6.7 ± 5.8 (20) | +1.01 (−1.91, +3.93) | ||
| 15 months | −6.0 ± 5.6 (24) | −4.9 ± 5.6 (22) | +0.02 (−2.89, +2.92) | ||
| Manifest astigmatism (D) | |||||
| 6 months | 4.1 ± 2.9 (25) | 4.4 ± 2.4 (21) | −0.22 (−1.66, +1.22) | 0.956 | 0.854 |
| 12 months | 4.1 ± 2.7 (24) | 3.9 ± 2.1 (20) | +0.26 (−1.21, +1.74) | ||
| 15 months | 4.4 ± 2.5 (24) | 4.3 ± 2.0 (22) | −0.12 (−1.55, +1.32) | ||
| Central corneal thickness (μm) | |||||
| 6 months | 572 ± 79 (28) | 551 ± 34 (23) | +16.8 (−14.5, +48.1) | 0.220 | 0.148 |
| 12 months | 583 ± 72 (24) | 561 ± 34 (18) | +16.0 (−15.9, +48.0) | ||
| 15 months | 564 ± 31 (25) | 574 ± 40 (22) | +2.1 (−29.4, +33.6) | ||
| Endothelial cell count (cells/mm2) | |||||
| 6 months | 2482 ± 537 (22) | 2564 ± 438 (22) | −253.5 (−639.6, +132.5) | 0.419 | 0.265 |
| 12 months | 2543 ± 311 (22) | 2611 ± 311 (17) | −27.5 (−405.0, +350.0) | ||
| 15 months | 2573 ± 312 (22) | 2602 ± 300 (17) | +131.7 (−233.8, +497.2) | ||
FE-DALK femtosecond-enabled deep anterior lamellar keratoplasty, S-DALK standard deep anterior lamellar keratoplasty.
aOverall difference (treatment and time by treatment interaction combined).
bTime by treatment interaction only.