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. 2023 Aug 2;30(9):2167–2186. doi: 10.1038/s41418-023-01198-x

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© The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 8 — LncRNA-WAC-AS1 enriched in IRI-sEVs facilitates HBP metabolic acceleration by upregulating GFPT1 and promotes BACH2 O-GlcNAcylation in neighboring and distant cell populations; this further enhances BACH2-mediated transcriptional suppression of SLC7A11 and GPX4, accordingly inducing ferroptosis spread.