Table 6.

Molecular docking glid G-scoring, RMSD, interaction results of the investigated compounds towards FGFR1 receptor (PDB ID: 5UR1).

Compounds	Glid G-score	RMSD	Interaction	Type	Distance
Re-docked inhibitor	− 6.290	0.792	NH→ALA564	H-Bond	2.34
			ASP641→(C–O)	H-Bond	2.17
			ALA564→(C = N)	H-Bond	2.34
			LYS514—Ar. ring	π-cation	5.51
			ASP641→Cl	halogen bond	2.92
Doxorubicin	− 5.760	0.565	OH→ASN628	H-Bond	1.97
			ASN568→(C=O)	H-Bond	2.58
			ASP641→(C=O)	H-Bond	2.63
			ASP641→(C–O)	H-Bond	2.60
			LYS514—Ar. ring	π-cation	5.19
2e	No interaction
2f	− 3.015	0.814	ARG576→(N=O)	H-Bond	1.85
			ARG576—(N=O–)	Salt bridge	4.83
			LYS566—(N=O–)	Salt bridge	4.79
			LYS482—Ar. ring	π-cation	6.31
4d	− 2.002	0.789	LYS482—(N=O–)	Salt bridge	2.9
			LYS482—Ar. ring	π-cation	6.29
4c	No interaction
2d	No interaction
4b	No interaction
2a	− 5.440	1.900	OH→ASP641	H-Bond	1.63
			LYS514→OH	H-Bond	2.39
2b	− 3.744	1.764	ASP641→OH	H-Bond	2.06
4a	− 1.978	1.925	NH→ASP641	H-Bond	2.1
2c	No interaction

Glide G-score: Kcal/mol, RMSD and distance: Å.