Fig. 1. Example of a dual fold contact map from experimentally determined structures.

KaiB monomeric/tetrameric heavy-atom contacts within 8 Å are shown in the upper/lower triangles of the contact map in light gray/black. Contacts common to both folds are shown in medium gray. Interchain contacts within 10 Å are shown as smaller circles in their respective colors. Monomeric/tetrameric contacts were calculated from PDBs 1T4Y/4KSO. Protein structures were generated with PyMOL⁸⁰. Plots in all figures were generated with Matplotlib⁸¹. Source data are provided as a Source Data file.