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. 2023 Apr 17;13(5):841–853. doi: 10.1016/j.jceh.2023.04.002

Table 2.

Modifications of MELD.

Name of MELD Year of introduction Modifications Comments
MELD XI 2007 Included only creatinine and bilirubin
  • -

    Suited for those who are on anticoagulation
Integrated MELD (iMELD) 2007 Includes sodium and age
  • -

    Increased accuracy in predicting mortality
MELD Na 2008 Sodium
  • -

    Serum sodium concentration is an important predictor of survival
D-MELD 2009 Donor age x MELD score
  • -

    <1600 predicts better survival
UKELD 2011 Similar to MELD Na, in UK.
Different coefficients
  • -

    UKELD >49 predicts mortality of >9% at 1 year

  • -

    UKELD >60 = 50% 1 year mortality
Recalibrated MELD 2013 Multivariate model recalibration
  • -

    Predicting 6-week mortality in acute variceal bleeding
ReFit MELD
ReFit MELD Na		 2017 Updated coefficients, change upper and lower bounds, and incorporate serum sodium
  • -

    improved wait-list mortality prediction
MELD Na with LFI 2017 C-statistic of 0.77 to predict wait-list mortality.
  • -

    Reclassify appropriately 19% of non-delistings
MELD Lactate 2020 Lactate
  • -

    Early and objective predictor of inpatient mortality
MELD 3.0 2021 Albumin, Female sex added
  • -

    More accurate mortality prediction

  • -

    Addresses sex disparity

LFT, liver frailty index; MELD, model for end-stage liver disease; Na, sodium.