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. Author manuscript; available in PMC: 2024 Apr 25.
Published in final edited form as: Mol Psychiatry. 2023 Mar 7;28(12):5262–5271. doi: 10.1038/s41380-023-02014-1

Fig. 1. Discovery of four genome-wide significant risk loci for mood disorders in the Old Order Amish founder population (n = 1672).

Fig. 1

A Manhattan plot: −log10(p values) for associations of single-nucleotide polymorphisms (SNPs) with mood disorders in the OOA. B Carriers of the lead SNP at the 7q22 risk locus are related within ten OOA families. Y-axis indicates the coefficient of relatedness from an empirical kinship matrix, with the dotted line at 0.5 indicating first-degree relatives. a ACP, b AMBiGen, c ASMAD, d TOPMed.