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. 2023 Aug 23;26(9):107707. doi: 10.1016/j.isci.2023.107707

Figure 2.

Figure 2

Nuclear proteome from seizure-induced forebrain excitatory neurons

(A) Chart showing percentage of mapped proteins annotated in the nucleus by PANTHER GO classification.

(B) Histogram showing relative frequency of log2 [mean abundance ratio] (MAR) between pilocarpine and mock-injected mice for N = 2608. The top 15% of total proteins with highest absolute log2MARs are highlighted in green for enriched (N = 196; log2MAR >0.1203) or red for depleted (N = 195; log2MAR < −0.1204) nuclear proteins.

(C) Top 10 GO terms ranked by enrichment scores across all three GO categories for proteins that are either enriched or depleted during seizures. GO classifications were performed separately for enriched or depleted pools of proteins.

(D) STRING network for seizure-enriched nuclear proteins (N = 196; Interaction score >0.7 with disconnected nodes from hidden from network). Magnified network highlights nodes of interest from the entire network (boxed inset).