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. 2023 Aug 23;26(9):107707. doi: 10.1016/j.isci.2023.107707

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Comparison between nuclear protein and mRNA levels during seizures

(A) Plot comparing log2 fold changes (LFCs) in the nuclear transcriptome and proteome (N = 2509). Genes with FDR <1% in the transcriptome and LFC in the top 15% of the proteome are highlighted and colored according to quadrant. Quadrants are labeled Q1-4.

(B) STRING protein interaction network of DE genes/proteins with annotated interactions (confidence ≥0.4). Node color corresponds to quadrant. Subsets of highly connected nodes in Q2 (bZIP transcription factors) and Q4 (actin cytoskeleton) are circled and adjacent GSEA plots for the corresponding gene sets in the transcriptome and proteome are presented.