REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
pCREB	Cell Signaling Technology	#9198
GRP78/BiP	Gifted from Dr. Y. Lian (NTU)	Not applicable.
GAPDH	Proteintech	Cat#60004-1-Ig
H3	Cell Signaling Technology	Cat#9715
LaminB1	Abcam	Cat#16048
FOS	Cell Signaling Technology	Cat#2250
GFP	Thermo Fisher Scientific	Cat#11122
GFP	NeuroMab	Cat#75-131
JUNB	Santa Cruz Biotechnology	Cat#8051
CUL4B	Sigma-Aldrich	Cat#011880
NEDD8	St John’s Laboratory	Cat#115482
SUMO1	Abcam	Cat#32058
SUMO2/3	Proteintech	Cat#11251-1-AP
SUMO-2/3	Cell Signaling Technology	Cat#4971
CaMKIIβ/γ	St John’s Laboratory	Cat#91990
NACC1	Santa Cruz Biotechnology	Cat#376216
GAD67	Merk Millipore	Cat##5406
THAP11	Proteintech	Cat#23030-1-AP
MAP2	PhosphoSolutions	Cat#1100
Alexa Fluor® 488 goat anti-mouse IgG (H + L)	Invitrogen	Cat#11001
Alexa Fluor® 555 goat anti-mouse IgG (H + L)	Invitrogen	Cat#21422
Alexa Fluor® 488 goat anti-rabbit IgG (H + L)	Invitrogen	Cat#11034
Alexa Fluor® 555 goat anti-rabbit IgG (H + L)	Invitrogen	Cat#21428
Alexa Fluor ® 647 goat anti-chicken IgY (H + L)	Invitrogen	Cat#21449
Goat anti-mouse light chain specific horseradish peroxidase (HRP)-conjugated	EMD Millipore	Cat#AP200P
Goat anti-rabbit IgG (H + L) HRP-conjugated	Bethyl Laboratories	Cat#A120-201P
VeriBlot for IP detection reagent (HRP)	Abcam	Cat#131366
Chemicals, peptides, and recombinant proteins
HBSS	Gibco	Cat#14170112
Trypsin	Life Technologies	Cat#15090046
DNAse	Sigma Aldrich	Cat#D5025
Trypsin Inhibitor	Sigma Aldrich	Cat#T9128
Neurobasal®-A medium	Gibco	Cat#10888022
Gentamycin	Gibco	Cat#15750045
FBS	Thermo Fisher Scientific	Cat#26140079
B27	Gibco	Cat#17504044
GlutaMAXTM	Gibco	Cat#35050061
Poly-D-Lysine	Sigma Aldrich	Cat#P7886
1(S),9(R)-(−)-Bicuculline methiodide	Sigma Aldrich	Cat#14343
TTX	Tocris	Cat#1078
Scopolamine methyl nitrate	Sigma Aldrich	Cat#S2250
Pilocarpine hydrochloride	Sigma Aldrich	Cat#P6503
IGEPAL®-CA 630	Sigma Aldrich	Cat#I8896
Dynabeads™ Protein G	Invitrogen	Cat#10-004-D
SYPRO® Ruby	Molecular Probes	Cat#S11791
TRIzol™ Reagent	Invitrogen	Cat#15-596-018
PowerUpTM SYBRTM Green	Applied Biosystems	Cat#A25741
Critical commercial assays
Pierce BCA Protein Assay Kit	Thermo Fisher Scientific	Cat#23227
PicoPure RNA isolation kit	Thermo Fisher Scientific	Cat#KIT0204
RevertAid First strand cDNA synthesis kit	Thermo Fisher Scientific	Cat#K1622
Deposited data
Mass Spectometry data	ProteomeXchange via PRIDE	Accession ID: PXD030637
RNA-sequencesing data	Gene Expression Omnibus (GEO)	Accession ID: GSE205454
Experimental models: Organisms/strains
Mice: B6; 129-Gt(ROSA)26Sortm5(CAG−Sun1/sfGFP)Nat/J	The Jackson Laboratory	Strain #021039
Mice: B6.Cg-Tg(CamkIIα-cre)T29−1Stl/J	The Jackson Laboratory	Strain #005359
Mice: C57BL6/J	The Jackson Laboratory via In Vivos Singapore	Strain #000664
Oligonucleotides
Fos Forward: CACACAGGACTTTTGCGC Reverse: GACACGGTCTTCACCATTCC	IDT	Generated internally, not applicable
Hprt Forward: TGTTGTTGGATATGCCCTTG Reverse: GGCCACAGGACTAGAACACC	IDT	Generated internally, not applicable
Junb Forward: TCACGACGACTCTTACGCAG Reverse: CCTTGAGACCCCGATAGGGA	IDT	Generated internally, not applicable
Zfp108 Forward: GCCCATCAGAGAGTTCATACC Reverse: CCCACACTCCACACACATATAC	IDT	Generated internally, not applicable
Zfp128 Forward: CCCTGGATACTGCTCAACATAC Reverse: TCAGGGCTTCTCCATGTTAATAC	IDT	Generated internally, not applicable
Zfp493 Forward: CCAGAGAATTCACACAGGAGAG Reverse: GCTGTTTAAGGGTGGAGGAATA	IDT	Generated internally, not applicable
Zfp660 Forward: CAGGCAGACATCTCAGGTTATT Reverse: GTAACGATAAGCTCTCCCACAC	IDT	Generated internally, not applicable
Zkscan7 Forward: GTGGCTATGGTGGAGGATTT Reverse: CTCAGTGCTCCCATCTTCTTT	IDT	Generated internally, not applicable
Software and algorithms
Image Lab	Bio-Rad	https://www.bio-rad.com/en-sg/product/image-lab-software?ID=KRE6P5E8Z
Zen Blue	Zeiss	https://www.micro-shop.zeiss.com/en/us/softwarefinder/software-categories/zen-blue/
ImageJ v1.53c	Fiji-ImageJ	https://imagej.nih.gov/ij/
IMARIS v9.7.2	Oxford Instruments	https://imaris.oxinst.com/
GraphPad Prism v9.1.2	GraphPad	https://www.graphpad.com/features
PANTHER v16	PANTHER maintained by P. Thomas laboratory	http://www.pantherdb.org/
STRING v11	STRING Consortium	https://string-db.org/
R v4.1.1	R Foundation	https://www.r-project.org/
Cytoscape v3.8.2	Cytoscape Team	https://cytoscape.org/