REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
GAPDH	Proteintech Group, Wuhan, Hubei, China	60004-1-Ig; RRID: AB_2107436
Collagen II	Proteintech Group, Wuhan, Hubei, China	15943-1-AP; RRID: AB_2881147
NRF2	Proteintech Group, Wuhan, Hubei, China	16396-1-AP; RRID: AB_2782956
HO-1	Proteintech Group, Wuhan, Hubei, China	10701-1-AP; RRID: AB_2118685
Parkin	Proteintech Group, Wuhan, Hubei, China	66674-1-Ig; RRID: AB_2882028
PINK1	Proteintech Group, Wuhan, Hubei, China	23274-1-AP; RRID: AB_2879244
NQO1	Abcam, Cambridge, UK	#ab80588; RRID: AB_1603750
MMP13	Abcam, Cambridge, UK	#ab39012; RRID: AB_776416
SOX9	Abcam, Cambridge, UK	#ab185966; RRID: AB_2728660
GPX4	Abcam, Cambridge, UK	#ab125066; RRID: AB_10973901
MMP3	Boster, Wuhan, Hubei, China	#BM4074
iNOS	Cell Signaling Technology, Beverly, MA, USA	#13120; RRID: AB_2687529
LC3	Cell Signaling Technology, Beverly, MA, USA	#4108; RRID: AB_2137703
COX2	Cell Signaling Technology, Beverly, MA, USA	#12882; RRID: AB_2571729
HRP Conjugated AffiniPure Goat Anti-mouse IgG	Boster, Wuhan, Hubei, China	BA1050
HRP Conjugated AffiniPure Goat Anti-rabbit IgG	Boster, Wuhan, Hubei, China	BA1054
FITC Conjugated AffiniPure Goat Anti-rabbit IgG	Boster, Wuhan, Hubei, China	BA1105
FITC Conjugated AffiniPure Goat Anti-mouse IgG	Boster, Wuhan, Hubei, China	BA1101
Chemicals, peptides, and recombinant proteins
Mitoquinone mesylate	Selleckchem, Houston, TX, USA	S8978
Erastin	Selleckchem, Houston, TX, USA	S7242
Recombinant mouse IL-1β protein	R&D Systems, Minneapolis, MN, USA	NP_032387
Trypsin	Biosharp Life Sciences, Hefei, Anhui, China	BL527A
Collagenase II	Biosharp Life Sciences, Hefei, Anhui, China	BS164
4% Paraformaldehyde	Biosharp Life Sciences, Hefei, Anhui, China	BL539A
DMEM/F12 medium	Hyclone, Logan, UT, USA	SH30023.01
Fetal bovine serum Excellent	NEWZERUM LIMITED, Upper Riccarton, Christchurch, New Zealand	E500
RNA isolation kit	Omega Bio-tek, USA	R6834-01
cDNA synthesis kit	Yeasen, Shanghai, China	11141ES60
Mitotracker Deep Red FM	Yeasen, Shanghai, China	40743ES50
RT-qPCR kit	Yeasen, Shanghai, China	11201es08
ROS assay kit	Beyotime, Shanghai, China	S0033
Nuclear and Cytoplasmic Protein Extraction Kit	Beyotime, Shanghai, China	P0027
C11-BODIPY Lipid Peroxidation Sensor	Thermo Fisher, Waltham, MA	D3861
RIPA lysis buffer	Boster, Wuhan, Hubei, China	AR0102
Protease inhibitors	Boster, Wuhan, Hubei, China	AR1182
Phosphatase inhibitors	Boster, Wuhan, Hubei, China	AR1183
DAPI reagent	Boster, Wuhan, Hubei, China	AR1176
Cell counting kit-8 (CCK-8)	Boster, Wuhan, Hubei, China	AR1160
FerroOrange	DOJINDO, ShangHai, China	F374
Safranin O Stain Solution	Solarbio Life Sciences, Beijing, China	G1067
Toluidine Blue Stain Solution	Solarbio Life Sciences, Beijing, China	G3660
PVDF membranes	Immobilon, USA	ISEQ00010
SDS-PAGE gels	BioRad, Hercules, CA, USA	4561036
Experimental models: Organisms/strains
C57BL/6J mouse	GemPharmatech, Nanjing, China	Strain NO.N000013
Oligonucleotides
Primer for RT-qPCR, see below table	This paper	N/A
Software and algorithms
ImageJ Version 1.52i	National Institutes of Health	https://www.nih.gov/
GraphPad Prism Version 8	GraphPad Software	https://www.graphpad.com/
Adobe Photoshop CC Version 19.0	Adobe	https://www.adobe.com/