Table 3. Fine & Gray model for multivariable analysis of time to event (emergency department consultation and unplanned hospital admission) with death as competitive risk.

Variables included in the analysis	Emergency department visit				Unplanned hospital admission
	SHR	95% CI	P		SHR	95% CI	P
Stage
IA–IIB	Reference	–	–		Reference	–	–
IIIA–IIIC	1.38	1.03–1.84	0.030		1.64	1.14–2.36	0.008
IVA–IVB	1.69	1.26–2.25	<0.001		2.00	1.41–2.85	<0.001
ECOG PS
0	Reference	–	–		Reference	–	–
1	1.03	0.84–1.27	0.752		1.05	0.83–1.33	0.706
2	1.28	0.95–1.71	0.101		1.88	1.39–2.53	<0.001
3	0.71	0.45–1.10	0.125		1.34	0.85–2.11	0.205
4	0.30	0.08–1.10	0.070		1.02	0.33–3.15	0.04
Age
<50 years	Reference	–	–		Reference	–	–
50–64 years	1.28	0.88–1.86	0.196		1.27	0.84–1.93	0.253
65–74 years	1.35	0.92–1.98	0.127		1.30	0.85–1.98	0.219
≥75 years	1.25	0.82–1.89	0.305		1.11	0.71–1.74	0.650
Sex
Female	Reference	–	–		Reference	–	–
Male	1.13	0.95–1.36	0.171		1.25	1.02–1.54	0.035
Histology
NSCLC	Reference	–	–		Reference	–	–
SCLC	1.11	0.92–1.35	0.279		1.06	0.84–1.34	0.633
Tobacco use
Non smoker	Reference	–	–		Reference	–	–
Former smoker	1.11	0.80–1.54	0.518		1.41	0.95–2.09	0.090
Active smoker	1.15	0.84–1.58	0.368		1.44	0.97–2.13	0.070
Drug use
No drug use	Reference	–	–		Reference	–	–
Opioids use	1.10	0.88–1.36	0.416		1.34	1.05–1.71	0.017
Steroids use	1.06	0.85–1.32	0.630		1.32	1.04–1.67	0.023
Symptoms
No symptom present	Reference	–	–		Reference	–	–
Cough	0.99	0.84–1.18	0.986		0.95	0.79–1.15	0.604
Dyspnoea	1.12	0.92–1.35	0.255		1.21	0.99–1.49	0.068
Pain	1.20	0.99–1.45	0.062		1.16	0.93–1.43	0.181

SHR, subhazard ratio; ECOG PS, Eastern Cooperative Oncology Group Performance Status; NSCLC, non-small cell lung cancer; SCLC, small cell lung cancer.