Table 4. Direct and indirect effects of obesity on ASCVD using difference method in men and women: exposure in binary and mediators in binary.

	ASCVD	Stroke			IHD
		All	Ischemic	Hemorrhagic	All	AMI	Angina
	Parameter (B)	Parameter (B)	Parameter (B)	Parameter (B)	Parameter (B)	Parameter (B)	Parameter (B)
Men
Total effect (TE)	0.23	0.20	0.28	0.12	0.22	0.17	0.20
Direct effect (DE)	0.16	0.10	0.17	−0.02	0.18	0.11	0.17
Indirect effect (TE-DE)	0.07	0.10	0.11	0.14	0.04	0.05	0.04
% mediated	30.7	48.8	39.5	NE	18.5	32.6	17.5
Women
Total effect (TE)	0.36	0.16	0.21	0.10	0.53	0.68	0.62
Direct effect (DE)	0.20	0.05	0.08	−0.03	0.39	0.48	0.49
Indirect effect (TE-DE)	0.16	0.11	0.14	0.12	0.14	0.21	0.13
% mediated	43.9	66.5	63.1	NE	26.2	30.0	21.0

AMI, acute myocardial infarction; ASCVD, atherosclerotic cardiovascular disease; IHD, ischemic heart disease; NE, not estimated due to small sample or insignificant results.

Total effect: adjusted for age, smoking, alcohol, exercise, systolic blood pressure (SBP), fasting glucose, and total cholesterol at baseline (’92 and ’94); Direct effect: adjusted for age, smoking, alcohol, exercise, SBP, fasting glucose, and total cholesterol at baseline plus mediators (hypertension, diabetes, and dyslipidemia) (’02 and ’04); % mediated: (TE-DE)/TE * 100.