Table 6. Mediators of the obesity on stroke and IHD risk among women: decomposing the direct and indirect effects.

Decomposing effect of mediators	ASCVD	Total stroke	Ischemic	Hemorrhagic	IHD
	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)
Hypertension
Crude effect	1.63 (1.39–1.91)	1.31 (1.02–1.68)	1.12 (0.66–1.92)	1.12 (0.61–2.05)	2.03 (1.63–2.54)
Natural direct effect	1.61 (1.39–1.86)	1.30 (1.03–1.64)	1.20 (0.76–1.90)	1.23 (0.76–2.00)	1.95 (1.58–2.41)
Natural indirect effect	1.05 (1.02–1.09)	1.06 (1.00–1.12)	1.15 (1.00–1.33)	1.25 (1.06–1.48)	1.00 (0.96–1.04)
Total effect	1.69 (1.47–1.94)	1.38 (1.11–1.71)	1.38 (0.91–2.10)	1.54 (1.00–2.37)	1.96 (1.60–2.40)
% of mediated (SE)	12.4	19.9	4.83	57.4	0.5
Diabetes
Crude effect	1.51 (1.30–1.76)	1.20 (0.94–1.52)	1.21 (0.75–1.94)	1.50 (0.96–2.34)	1.73 (1.38–2.17)
Natural direct effect	1.49 (1.29–1.72)	1.19 (0.95–1.50)	1.21 (0.77–1.90)	1.46 (0.94–2.26)	1.70 (1.37–2.12)
Natural indirect effect	1.03 (1.01–1.06)	1.03 (1.00–1.07)	1.10 (1.00–1.20)	0.99 (0.95–1.04)	1.04 (1.00–1.07)
Total effect	1.54 (1.34–1.77)	1.23 (0.99–1.54)	1.33 (0.88–2.00)	1.45 (0.95–2.22)	1.77 (1.44–2.17)
% of mediated (SE)	9.5	17.6	35.2	−2.0	8.4
Dyslipidemia
Crude effect	1.40 (1.13–1.75)	1.03 (0.73–1.46)	0.98 (0.48–1.99)	1.11 (0.57–2.18)	1.85 (1.35–2.55)
Natural direct effect	1.51 (1.27–1.79)	1.19 (0.91–1.54)	1.27 (0.78–2.07)	1.17 (0.68–2.00)	1.83 (1.42–2.37)
Natural indirect effect	1.03 (1.00–1.06)	1.05 (1.00–1.09)	1.08 (0.99–1.18)	1.02 (0.94–1.10)	1.01 (0.97–1.05)
Total effect	1.55 (1.32–1.83)	1.24 (0.97–1.60)	1.37 (0.86–2.18)	1.19 (0.71–2.00)	1.85 (1.44–2.37)
% of mediated (SE)	7.9	22.5	27.1	10.8	2.5

ASCVD, atherosclerotic cardiovascular disease; CI, confidence interval HR, hazard ratio, adjusted for age, smoking, alcohol, and exercise; IHD, ischemic heart disease; SE, standard error.