Table 2.

Relationship between renal function and atrial fibrillation incidence.

	Number of participants	Number of events	Event rate (%) (95% CI)	Person-years	Incidence rate (per 1,000 person-years)	Adjusted HR (95% CI)	p-value
eGFR (decile), mL/min/1.73 m2
1st (< 67.51)	263,451	6,838	2.60 (2.53, 2.66)	2,403,195.33	2.85	1.08 (1.03, 1.13)	0.010
2nd (67.51–75.08)	266,010	4,236	1.59 (1.54, 1.64)	2,512,757.54	1.69	1.05 (1.00, 1.10)	0.034
3rd (75.08–80.69)	265,650	3,065	1.15 (1.11, 1.19)	2,532,633.50	1.21	1.05 (1.00, 1.11)	0.056
4th (80.69–86.05)	271,300	2,752	1.01 (0.98, 1.05)	2,575,152.64	1.07	0.96 (0.91, 1.01)	0.130
5th (86.05–90.49)	254,182	2,815	1.11 (1.07, 1.15)	2,413,161.20	1.17	1 (Reference)
6th (90.49–95.50)	262,462	2,721	1.04 (1.00, 1.08)	2,498,383.35	1.09	1.02 (0.97, 1.08)	0.443
7th (95.50–100.55)	271,764	2,279	0.84 (0.80, 0.87)	2,600,312.54	0.88	1.04 (0.98, 1.10)	0.216
8th (100.55–105.63)	261,435	1,352	0.52 (0.49, 0.54)	2,506,681.16	0.54	0.91 (0.85, 0.97)	0.006
9th (105.63–113.41)	264,354	944	0.36 (0.33, 0.38)	2,531,735.26	0.37	0.83 (0.77, 0.89)	<0.001
10th (≥ 113.41)	264,434	467	0.18 (0.16, 0.19)	2,531,292.14	0.18	0.77 (0.70, 0.85)	<0.001
eGFR(range), mL/min/1.73 m2
< 30	2,774	116	4.18 (3.42, 4.94)	19,998.23	5.80	1.22 (1.01, 1.46)	0.039
30–60	112,121	3,494	3.12 (3.01, 3.22)	994,408.94	3.51	1.02 (0.98, 1.06)	0.308
60–90	1,185,354	15,896	1.34 (1.32, 1.36)	11,227,881.41	1.42	1 (Reference)
90–120	1,235,776	7,770	0.63 (0.61, 0.64)	11,820,400.43	0.66	0.95 (0.92, 0.98)	<0.001
> 120	109,017	193	0.18 (0.15, 0.20)	1,042,615.65	0.19	0.88 (0.78, 0.98)	0.045

The multivariable model was adjusted for sex, age, body mass index, waist circumference, income levels, smoking, alcohol consumption, regular physical activity, proteinuria, hypertension, diabetes mellitus, dyslipidemia, heart failure, myocardial infarction, valvular heart disease, cardiomyopathy, congenital heart disease, hyperthyroidism, and Charlson comorbidity index. CI, confidence interval; HR, hazard ratio; eGFR, estimated glomerular filtration rate.