Table 2:

Genotyping of single-nucleotide polymorphism of NT-3 gene (rs6489630, rs6332, and rs11063714) between schizophrenia and controls.

Polymorphism	Genotype	Schizophrenia cases (n=216) (%)	Control (n=216), (%)	P	OR (95% CI)
rs6489630	CT	95 (44.0)	74 (34.3)	0.02	1.631 (1.10–2.43)
	TT	16 (7.4)	8 (3.7)	0.05	2.55 (1.05–6.19)
	CC	105 (48.6)	134 (62.0)	Ref	1.58 (1.16–2.16)
Minor allele	T	127 (29.4)	90 (20.8)	0.004	1.72 (1.18–2.53)
Major allele	C	305 (70.6)	342 (79.2)	Ref	0.48 (0.20–1.15)
Dominant model analysis	CT+TT	111 (51.4)	82 (37.9)	0.006	0.66 (0.45–0.98)
	CC	105 (48.6)	134 (62.1)	Ref
Recessive model analysis	CC+CT	200 (92.6)	208 (96.3)	0.140
	TT	16 (7.4)	8 (3.7)	Ref
Codominant model analysis	CC+TT	121 (56.1)	142 (65.7)	0.048
	CT	95 (43.9)	74 (33.3)	Ref
rs6332	AG	114 (52.7)	104 (48.1)	0.608	1.15 (0.75–1.76)
	AA	36 (16.8)	43 (20.0)	0.743	0.87 (0.50–1.52)
	GG	66 (30.5)	69 (31.9)	Ref	0.96 (0.74–1.26)
Minor allele	A	186 (43.1)	190 (44.0)	0.836	1.67 (0.71–1.6)
Major allele	G	246 (56.9)	242 (56.0)	Ref	1.24 (0.76–2.03)
Dominant model analysis	AG+AA	150 (69.4)	147 (68.0)	0.835	0.83 (0.569–0.121)
	GG	66 (30.6)	69 (32.0)	Ref
Recessive model analysis	GG+AG	180 (83.3)	173 (80.0)	0.455
	AA	36 (16.7)	43 (20.0)	Ref
Codominant model analysis	GG+AA	102 (47.2)	112 (51.8)	0.386
	AG	114 (52.8)	104 (48.2)	Ref
rs11063714	AG	184 (85.5)	191 (88.5)	0.393	0.7526 (0.42–1.3)
	GG	32 (14.8)	25 (11.5)	Ref	0.93 (0.71–1.21)
	AA	0	0	-
Minor allele	A	184 (42.6)	191 (44.2)	0.680
Major allele	G	248(57.4)	241 (55.8)	Ref

rs6489630: HWE for cases - χ²=0.76, P=0.381; HWE for controls, χ²=0.32, P=0.570. rs6332: HWE for cases - χ²=1.25, P=0.262; HWE for controls, χ²=0.113, P=0.736. rs11063714: HWE for cases - χ²=135.6, P=0.0001; HWE for controls, χ²=118.91, P=0.0001. HWE: Hardy–Weinberg equilibrium, OR: Odds ratio, CI: Confidence interval, NT-3: Neurotrophin-3