Supplementary Table 4:
NT-3 genetic variants in schizophrenia cases with normal cognitive function and mild and severe cognitive impairment.
| Genotype | Schizophrenia cases | P-value | ||
|---|---|---|---|---|
| Severe cognitive impairment (ACE III score: 0–61) (n=88) (%) | Mild cognitive impairment (ACE III score: 62–81) (n=93) (%) | Normal cognitive function (ACE III score: 82–100) (n=35) (%) | ||
| rs6489630 | ||||
| CC | 40 (45.5) | 50 (53.7) | 15 (42.8) | 0.377 |
| CT | 42 (47.7) | 38 (40.8) | 15 (42.8) | |
| TT | 6 (11.8) | 5 (5.5) | 5 (14.2) | |
| rs6332 | ||||
| GG | 20 (22.7) | 28 (30.1) | 18 (51.4) | 0.040 |
| AG | 51 (57.9) | 49 (52.7) | 14 (40.) | |
| AA | 17 (19.3) | 16 (17.2) | 3 (8.6) | |
| rs11063714 | ||||
| AG | 73 (82.9) | 78 (83.8) | 32 (91.4) | 0.250 |
| GG | 15 (17.1) | 15 (16.2) | 3 (9.6) | |
| NT-3 (ng/L) | 187.0 (117.0–289.0) | 134.0 (206.0–276.0) | 211.0 (137.0–348.0) | 0.443 |
NT-3: Neurotrophin-3, ACE-III: Addenbrooke cognitive examination-III