TABLE 7.

Results of pairwise meta-analyses for the ADAS-cog score.

Comparative	Reference medications	Number of studies	Number of controls	Number of patients	MD/OR	95% CI	I2	p
Donepezil	Placebo	7	199	201	−0.76	[-2.10, 0.58]	0	0.001
Actovegin	Placebo	9	244	255	−3.70	[-5.5, −1.9]	0	0.001
GAL	Placebo	9	390	396	−1.67	[-3.36, −0.06]	0	0.0001
MEM	Placebo	9	284	396	−2.17	[-3.91, −0.53]	0	0.0001
RIV	Placebo	9	326	404	−0.28	[-1.89, 1.82]	0	0.0001
EGB761	Placebo	8	1,285	1,296	−2.86	[-3.18, −2.54]	NA	0.00001
Nimodipine	Placebo	12	247	243	−7.59	[-9.87, −5.31]	0	0.0001

CI, confidence interval; MD, mean difference; OR, risk ratio; I², heterogeneity, MEM, memantine; GAL, galantamine; RIV, rivastigmine.