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. 2023 Aug 24;15:1223977. doi: 10.3389/fnagi.2023.1223977

FIGURE 1.

FIGURE 1

Schematic representation of behavior cellular and molecular changes associated with AD-like symptoms in mice. (A) Natural history of factors involved in the pathogenesis of Alzheimer’s disease (AD) in ALDH2–/– mice. (B) Natural history of factors involved in the pathogenesis of AD in ALDH2*2 overexpressing (OE) transgenic mice. (C) Natural history of factors involved in the pathogenesis of mice expressing AD-associated amyloid precursor protein (APP). (D) Natural history of factors involved in the pathogenesis of mice expressing APP, and overexpressing ALDH2*2. 4-HNE, 4-hydroxynon-enal; Aβ, amyloid β; pTau, phosphorylated tau; Casp-3, Caspase 3; pCREB, phosphorylated cyclic-AMP response element binding protein.