Table 2. Prediagnosis Logistic Regression Models for Psychotic Disorder and Nonpsychotic Bipolar Disorder.
| Exposure | OR (95% CI) | |||||
|---|---|---|---|---|---|---|
| Psychotic disorder | Nonpsychotic bipolar disorder | |||||
| Univariable model | Bivariable modela | Multivariable modelb | Univariable model | Bivariable modela | Multivariable modelb | |
| Deprivation index | ||||||
| Trajectory 1 (least deprived) | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| Trajectory 2 | 1.10 (1.02-1.19) | 1.16 (1.07-1.25) | 1.03 (0.95-1.12) | 1.21 (1.13-1.30) | 1.26 (1.17-1.36) | 1.14 (1.06-1.24) |
| Trajectory 3 | 1.38 (1.27-1.49) | 1.45 (1.34-1.57) | 1.17 (1.06-1.26) | 1.42 (1.32-1.53) | 1.51 (1.40-1.63) | 1.25 (1.16-1.36) |
| Trajectory 4 (most deprived) | 1.62 (1.50-1.75) | 1.56 (1.43-1.69) | 1.17 (1.08-1.28) | 1.42 (1.32-1.53) | 1.50 (1.39-1.63) | 1.23 (1.13-1.34) |
| Trajectory 5 (strong upward mobility) | 1.25 (1.12-1.38) | 1.22 (1.10-1.35) | 1.01 (0.91-1.12) | 1.29 (1.17-1.42) | 1.26 (1.14-1.39) | 1.08 (0.97-1.19) |
| Trajectory 6 (moderate upward mobility) | 1.46 (1.33-1.60) | 1.46 (1.33-1.60) | 1.11 (1.01-1.23) | 1.50 (1.38-1.64) | 1.53 (1.40-1.68) | 1.21 (1.10-1.33) |
| Population density | ||||||
| Trajectory 1 (least densely populated) | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| Trajectory 2 | 1.14 (1.02-1.28) | 1.22 (1.09-1.36) | 1.08 (0.96-1.21) | 1.13 (1.02-1.26) | 1.19 (1.07-1.32) | 1.07 (0.97-1.19) |
| Trajectory 3 | 1.26 (1.14-1.40) | 1.42 (1.28-1.58) | 1.17 (1.05-1.31) | 1.12 (1.01-1.23) | 1.25 (1.13-1.38) | 1.06 (0.96-1.18) |
| Trajectory 4 | 1.36 (1.23-1.50) | 1.55 (140-1.71) | 1.21 (1.08-1.34) | 1.23 (1.12-1.35) | 1.41 (1.28-1.55) | 1.16 (1.05-1.28) |
| Trajectory 5 (most densely populated) | 1.96 (1.77-2.16) | 1.98 (1.79-2.19) | 1.49 (1.34-1.66) | 1.23 (1.12-1.36) | 1.27 (1.15-1.41) | 1.08 (0.97-1.20) |
| Trajectory 6 (urban-rural movement) | 1.69 (1.49-1.91) | 1.82 (1.60-2.06) | 1.29 (1.13-1.47) | 1.58 (1.40-1.78) | 1.69 (1.49-1.90) | 1.24 (1.09-1.41) |
| Parental migrant status | 1.73 (1.63-1.84) | NA | 1.43 (1.33-1.52) | 1.12 (1.05-1.19) | NA | 1.02 (0.96-1.09) |
| Parental history of SMI | 3.94 (3.52-4.40) | NA | 3.44 (3.08-3.85) | 4.28 (3.86-4.75) | NA | 3.87 (3.48-4.30) |
| Parental disposable income at birth | ||||||
| 1 (Lowest quintile) | 1 [Reference] | NA | 1 [Reference] | 1 [Reference] | NA | 1 [Reference] |
| 2 | 0.72 (0.67-0.78) | NA | 0.83 (0.77-0.90) | 0.95 (0.88-1.02) | NA | 1.05 (0.97-1.14) |
| 3 | 0.64 (0.59-0.69) | NA | 0.80 (0.74-0.87) | 0.85 (0.79-0.91) | NA | 0.99 (0.92-1.07) |
| 4 | 0.66 (0.61-0.71) | NA | 0.86 (0.79-0.93) | 0.73 (0.68-0.79) | NA | 0.90 (0.83-0.97) |
| 5 (Highest quintile) | 0.63 (0.58-0.68) | NA | 0.83 (0.76-0.90) | 0.79 (0.73-0.85) | NA | 1.01 (0.93-1.10) |
| Moves between birth and 14th year | 1.21 (1.19-1.24) | NA | 1.16 (1.14-1.18) | 1.21 (1.19-1.23) | NA | 1.16 (1.14-1.18) |
Abbreviations: NA, not applicable; OR, odds ratio; SMI, severe mental illness.
a
Adjusted for deprivation index and population density trajectory membership and controlling for birth year and sex by matching cases and controls.
b
Adjusted as in the bivariable model and for parental migrant status, parental history of SMI, parental disposable income at birth, and number of moves (between birth and 14th year).