Table 1.
Annotation of individual genes of iron-uptake clusters
|
Gene |
Locus tag* |
Gene annotation |
|
|---|---|---|---|
|
feoA |
DMO12_RS01455 |
Ferrous iron transport protein A |
|
|
feo |
feoB |
DMO12_RS01460 |
Ferrous iron transport protein B |
|
feoC |
DMO12_RS01465 |
Ferrous iron transport protein C |
|
|
exbD |
DMO12_RS08415 |
Biopolymer transporter ExbD |
|
|
exbD |
DMO12_RS08420 |
Biopolymer transporter ExbD |
|
|
exbB |
DMO12_RS08425 |
MotA/TolQ/ExbB proton channel family protein |
|
|
tonB |
DMO12_RS08430 |
Energy transducer TonB |
|
|
hemTR |
DMO12_RS08435 |
TonB-dependent receptor |
|
|
hemT |
– |
DMO12_RS08445 |
Haem-binding protein |
|
– |
DMO12_RS08450 |
Haem-binding protein |
|
|
– |
DMO12_RS08455 |
Oligopeptidase |
|
|
– |
DMO12_RS08460 |
ABC permease |
|
|
– |
DMO12_RS08465 |
ABC permease |
|
|
– |
DMO12_RS08470 |
ATP-binding protein |
|
|
– |
DMO12_RS08475 |
Hypothetial protein |
|
|
– |
DMO12_RS04685 |
ECF-sigma factor |
|
|
– |
DMO12_RS04690 |
Anti-sigma factor |
|
|
hphR |
DMO12_RS04695 |
TonB-dependent receptor |
|
|
hemO |
hphA |
DMO12_RS04700 |
Slam-dependent haemophore |
|
hsmA |
DMO12_RS04705 |
Hemophilin secretion modulator |
|
|
– |
DMO12_RS04710 |
TonB-related protein |
|
|
– |
DMO12_RS04715 |
Haem oxygenase |
|
|
– |
DMO12_RS04720 |
Hypothetical protein |
|
|
basJ |
DMO12_RS13105 |
Acinetobactin biosynthesis isochorismate synthase |
|
|
basI |
DMO12_RS13110 |
Acinetobactin biosynthesis phosphopantetheinyl transferase |
|
|
basH |
DMO12_RS13115 |
Acinetobactin biosynthesis thioesterase |
|
|
barB |
DMO12_RS13120 |
Acinetobactin export ABC transporter permease/ATP-binding subunit |
|
|
barA |
DMO12_RS13125 |
Acinetobactin export ABC transporter permease/ATP-binding subunit |
|
|
– |
DMO12_RS13130 |
Hypothetical protein |
|
|
basG |
DMO12_RS13135 |
Acinetobactin biosynthesis histidine decarboxylase |
|
|
basF |
DMO12_RS13140 |
Acinetobactin biosynthesis bifunctional isochorismatase/aryl carrier protein |
|
|
basE |
DMO12_RS13145 |
(2,3-dihydroxybenzoyl) adenylate synthase |
|
|
bas/bau |
basD |
DMO12_RS13150 |
Acinetobactin non-ribosomal peptide synthetase subunit |
|
basC |
DMO12_RS13155 |
Putative histamine N-monooxygenase |
|
|
bauA |
DMO12_RS13160 |
TonB-dependent siderophore receptor |
|
|
bauB |
DMO12_RS13165 |
Siderophore-binding periplasmic lipoprotein |
|
|
bauE |
DMO12_RS13170 |
Ferric acinetobactin ABC transporter ATP-binding protein |
|
|
bauC |
DMO12_RS13175 |
Ferric acinetobactin ABC transporter permease subunit |
|
|
bauD |
DMO12_RS13180 |
Ferric acinetobactin ABC transporter permease subunit |
|
|
basB |
DMO12_RS13185 |
Acinetobactin non-ribosomal peptide synthetase subunit |
|
|
basA |
DMO12_RS13190 |
Acinetobactin non-ribosomal peptide synthetase subunit |
|
|
bauF |
DMO12_RS13195 |
Acinetobactin utilization protein |
|
|
entA |
DMO12_RS09220 |
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase |
|
|
bfnA |
DMO12_RS08630 |
Siderophore biosynthesis protein |
|
|
bfnB |
DMO12_RS08635 |
SidA/IucD/PvdA family monooxygenase |
|
|
bfnc |
DMO12_RS08640 |
DHA2 family efflux MFS transporter permease subunit |
|
|
bfnD |
DMO12_RS08645 |
Siderophore achromobactin biosynthesis protein AcsC |
|
|
bfnE |
DMO12_RS08650 |
LucA/LucC family siderophore biosynthesis protein |
|
|
bfn |
bfnF |
DMO12_RS08655 |
(2Fe-2S)-binding protein |
|
bfnG |
DMO12_RS08660 |
RraA family protein |
|
|
bfnH |
DMO12_RS08665 |
TonB-dependent receptor |
|
|
bfnI |
DMO12_RS08670 |
Hypothetical protein |
|
|
bfnJ |
DMO12_RS08675 |
PepSY domain-containing protein |
|
|
bfnK |
DMO12_RS08680 |
Hypothetical protein |
|
|
bfnL |
DMO12_RS08685 |
Acetyltransferase |
|
|
fbsA |
ACX60_RS04655 |
AraC family transcriptional regulator |
|
|
fbsB |
ACX60_RS04660 |
Isochorismate synthase |
|
|
fbsC |
ACX60_RS04665 |
Isochorismatase family protein |
|
|
fbsD/entA |
ACX60_RS04670 |
2,3-dihydroxybenzoate-2,3-dehydrogenase |
|
|
fbsE |
ACX60_RS04675 |
Peptide synthetase |
|
|
fbsF |
ACX60_RS04680 |
Peptide synthetase |
|
|
fbsG |
ACX60_RS04685 |
Peptide synthetase |
|
|
fbsH |
ACX60_RS04690 |
2,3-dihydroxybenzoate–AMP ligase |
|
|
fbs |
fbsI |
ACX60_RS04695 |
Alcaligin biosynthesis protein |
|
fbsJ |
ACX60_RS04700 |
Ornithine decarboxylase |
|
|
fbsK |
ACX60_RS04705 |
Siderophore biosynthesis protein |
|
|
TS1 |
ACX60_RS04710 |
Transposase |
|
|
TS2 |
ACX60_RS04715 |
Transposase |
|
|
fbsL |
ACX60_RS04720 |
Phosphopantetheinyl transferase |
|
|
fbsM |
ACX60_RS04725 |
Thioesterase |
|
|
fbsN |
ACX60_RS04730 |
TonB-dependent siderophore receptor |
|
|
fbsO |
ACX60_RS04735 |
MFS transporter |
|
|
fbsP |
ACX60_RS04740 |
Side-tail fibre protein |
|
|
fbsQ |
ACX60_RS04745 |
Multidrug transporter MatE |
*Locus tags and gene annotations refer to the A. baumannii ACICU genome (NZ_CP031380.1), except for the fbs gene cluster, which refers to the A. baumannii ATCC 17978 genome (NZ_CP012004.1).