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. 2023 Jul 7;49(5):1305–1315. doi: 10.1093/schbul/sbad100

Fig. 2.

Fig. 2.

Thirty-one promising drug targets were proposed for psychiatric disorders. (a) Forest plots showing the results that drug targets as an antagonist reached significance and pass stringent quality tests in the brain eQTL dataset (blue =PsychENCODE). (b) Forest plots showing the results that drug targets as an agonist reached significance and pass stringent quality tests in the brain eQTL dataset (blue =PsychENCODE). The “Indication” column indicates whether the corresponding drug is approved or proposed (the drug information can be retrieved through DrugBank). The term “NA” used in the plot represents encoded druggable genes that have not been included in the DrugBank. Replicated significant genes with concordant effect direction between blood and brain tissues are distinguished and bolded. Additionally, we calculated a 95% CI for the OR. SCZ: schizophrenia, BP: bipolar disorder, DEP: depressive disorder, ADHD: attention deficit hyperactivity disorder.