TABLE 1.

Extracellular and intracellular activities of various drugs against L. pneumophila 80-045 SG1

Drug	MIC (μg/ml)a	MIEC (μg/ml)b
Ampicillin	2	>64
Methicillin	4	64
Piperacillin	4	64
Cefazolin	64	>64
Cefotiam	2	>64
Ceftizoxime	0.125	>64
Cefotaxime	0.25	>64
Ceftazidime	0.125	>64
Imipenem	0.125	>64
Panipenem	0.125	>64
Gentamicin	2	32
Tobramycin	4	64
Erythromycin	0.125	1
Josamycin	0.125	0.063
Rokitamycin	0.063	0.031
Clarithromycin	0.031	0.031
Roxithromycin	0.063	0.125
Azithromycin	0.063	0.5
Levofloxacin	0.063	0.016
Ciprofloxacin	0.031	0.063
Sparfloxacin	0.004	0.004
Rifampin	0.002	0.004
Minocycline	2	0.25
Clindamycin	16	8

^aMICs were determined by the microdilution method in BYE-α broth, and the inoculum size was 10⁶ CFU/ml. 

^bMIECs represent the intracellular antimicrobial activities of antibiotics and were determined by the methods described in the text. Triplicate examinations showed that each drug had identical MIECs.