Table 1.
HLA-DRB1 alleles HLA-DRB1*04:04 and HLA-DRB1*04:01 are associated with a decreased risk of Parkinson’s and ADs
| HLA | PD | AD | PD + AD | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FreqC | N | OR | P-val | FreqC | N | OR | P-val | OR | P-val | p-het | ||
| HLA Alleles | HLA-DRB1*04:01 | 0.196 | 1,484,656 | 0.92[0.89; 0.95] | 2.4E-08 | 0.191 | 486,478 | 0.93[0.9; 0.96] | 6.4E-07 | 0.92[0.91; 0.94] | 8.9E-14 | 0.56 |
| HLA-DRB1*04:02 | 0.019 | 1,474,730 | 0.92[0.85; 0.99] | 0.02 | 0.022 | 155,846 | 1.00[0.91; 1.10] | 0.99 | 0.95[0.89; 1.01] | 0.07 | 0.17 | |
| HLA-DRB1*04:03 | 0.012 | 980,868 | 0.89[0.81; 0.97] | 0.01 | 0.072 | 7,587 | 1.09[0.91; 1.30] | 0.34 | 0.93[0.85; 1.01] | 0.07 | 0.04 | |
| HLA-DRB1*04:04 | 0.074 | 1,475,574 | 0.84[0.80; 0.88] | 1.5E-11 | 0.073 | 476,236 | 0.86[0.82; 0.90] | 8.9E-12 | 0.85[0.82; 0.88] | 9.3E-22 | 0.60 | |
| HLA-DRB1*04:05 | 0.013 | 1,507,057 | 1.00[0.95; 1.05] | 0.86 | 0.026 | 169,080 | 0.98[0.91; 1.06] | 0.62 | 0.99[0.95; 1.03] | 0.68 | 0.75 | |
| HLA-DRB1*04:06 | 0.046 | 32,327 | 0.95[0.82; 1.09] | 0.46 | 0.058 | 7,587 | 0.95[0.78; 1.15] | 0.60 | 0.95[0.85; 1.06] | 0.37 | 0.99 | |
| HLA-DRB1*04:07 | 0.021 | 526,189 | 0.79[0.69; 0.91] | 7.3E-04 | 0.019 | 474,840 | 0.88[0.81; 0.96] | 4.5E-03 | 0.86[0.79; 0.92] | 2.7E-05 | 0.18 | |
| HLA-DRB1*04:10 | 0.041 | 4,853 | 0.91[0.67; 1.25] | 0.57 | 0.031 | 7,985 | 1.23[0.94; 1.59] | 0.13 | 1.08[0.89; 1.32] | 0.42 | 0.16 | |
| HLA-DRB1*01:01 | 0.181 | 1,485,033 | 1.05[1.01; 1.09] | 7.0E-03 | 0.186 | 487,120 | 1.07[1.04; 1.10] | 3.9E-07 | 1.06[1.04; 1.09] | 1.3E-08 | 0.44 | |
| HLA-DQB1*03:02 | 0.191 | 1,501,065 | 0.91[0.88; 0.93] | 2.6E-14 | 0.190 | 510,130 | 0.89[0.86; 0.91] | 1.2E-19 | 0.90[0.88; 0.91] | 4.7E-32 | 0.23 | |
| HLA-DQA1*03:01 | 0.177 | 1,507,147 | 0.89[0.87; 0.91] | 2.5E-20 | 0.186 | 507,263 | 0.89[0.87; 0.91] | 1.8E-19 | 0.89[0.88; 0.91] | 3.E-37 | 0.79 | |
| HLA-DRB1*15:01 | 0.272 | 1,507,057 | 1.06[1.03; 1.10] | 5.0E-04 | 0.263 | 485,383 | 1.02[0.99; 1.04] | 0.13 | 1.03[1.01; 1.05] | 1.1E-03 | 0.054 | |
| HLA Haplotypes | DRB1*04:01~DQA1* 03:01~DQB1*03:02 | 0.088 | 1,473,386 | 0.95[0.92; 0.98] | 3.6E-03 | 0.092 | 342,115 | 0.91[0.87; 0.95] | 6.5E-06 | 0.93[0.91; 0.96] | 3.2E-07 | 0.10 |
| DRB1*04:01~DQA1* 03:03~DQB1*03:01 | 0.12 | 1,481,518 | 0.98[0.97; 0.99] | 5.2E-04 | 0.133 | 346,157 | 0.98[0.94; 1.02] | 0.36 | 0.98[0.97; 0.99] | 3.4E-04 | 0.86 | |
| DRB1*04:04~DQA1* 03:01~DQB1*03:02 | 0.077 | 1,475,734 | 0.84[0.80; 0.89] | 1.7E-10 | 0.086 | 344,760 | 0.85[0.81; 0.89] | 5.4E-11 | 0.85[0.82; 0.88] | 5.7E-20 | 0.78 | |
| DRB1*04:07~DQA1* 03:01~DQB1*03:02 | 0.198 | 1498 | 0.58[0.44; 0.76] | 6.1E-05 | 0.063 | 1,865 | 0.75[0.47; 1.21] | 0.23 | 0.62[0.49; 0.78] | 4.6E-05 | 0.36 | |
| DRB1*04:07~DQA1* 03:03~DQB1*03:01 | 0.021 | 524,845 | 0.87[0.73; 1.04] | 0.12 | 0.017 | 340,065 | 0.87[0.79; 0.97] | 8.0E-03 | 0.87[0.80; 0.95] | 2.1E-03 | 0.99 | |
| DRB1*04:05~DQA1* 03:03~DQB1*04:01 | 0.11 | 35,369 | 0.99[0.92; 1.06] | 0.76 | 0.21 | 4,149 | 0.97[0.83; 1.13] | 0.68 | 0.99[0.92; 1.05] | 0.65 | 0.81 | |
| DRB1*08:02~DQA1* 03:01~DQB1*03:02 | 0.026 | 5,602 | 1.10[0.76; 1.60] | 0.61 | 0.02 | 4,149 | 0.85[0.55; 1.31] | 0.46 | 0.99[0.74; 1.31] | 0.93 | 0.37 | |
| DRB1*01:01~DQA1* 01:01~DQB1*05:01 | 0.150 | 1,485,406 | 1.05[1.01; 1.09] | 0.02 | 0.222 | 351,276 | 1.08[1.05; 1.11] | 4.8E-07 | 1.07[1.04; 1.09] | 6.8E-08 | 0.27 | |
| Amino acid: | HLA-DRB1 13H/33H | 0.300 | 1,507,057 | 0.89[0.87; 0.91] | 9.3E-22 | 0.315 | 527,173 | 0.91[0.89; 0.93] | 1.7E-18 | 0.90[0.89; 0.92] | 2.0E-38 | 0.36 |
Effect sizes are reported as odds ratio (OR), with 95% CI, and significance (P-value). FreqC: frequency of carriers, N: number of individuals analyzed for a given allele/haplotype/amino acid, p-het: heterogeneity test P-value.