Table 2.

Univariate and multivariate analysis of prognostic factors for disease-free survival in CRC patients

Variable	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
UTX expression
Low expression	Reference		Reference
High expression	0.595 (0.383–0.925)	0.021	0.619 (0.394–0.972)	0.037
Age
≤ 60	Reference		NA
> 60	1.140 (0.763–1.703)		0.522
Sex
Male	Reference		NA
Female	0.762 (0.503–1.155)		0.200
Tumor Location
Colon	Reference		NA
Return	0.809 (0.544–1.202)		0.293
Preoperative Serum CEA
Normal	Reference		Reference
Elevated	2.606 (1.731–3.922)	< 0.001	1.985 (1.302–3.024)	0.001
pT stage
T2	Reference		Reference
T3	2.621 (0.845–8.127)	0.095	2.542 (0.805–8.029)	0.112
T4	6.546 (2.398–17.872)	< 0.001	4.074 (1.466–11.321)	0.007
pN stage
0	Reference		Reference
1	3.157 (1.836–5.427)	< 0.001	0.777 (0.378–1.599)	0.494
2	4.434 (2.621–7.501)	< 0.001	0.932 (0.463–1.875)	0.843
TNM stage
I + II	Reference		Reference
III + IV	6.041 (3.298–11.067)	< 0.001	6.111 (2.469–15.122)	< 0.001
Histologic type
Adenocarcinoma	Reference		NA
Mucinous adenocarcinoma	0.870 (0.354–2.141)	0.762
Grade
Well-Moderately differentiated	Reference		NA
Moderately-Poor differentiated	1.268 (0.512–3.141)	0.608
Vessel invasion
No	Reference		NA
Yes	1.240 (0.171–8.976)	0.831
Nerve invasion
No	Reference		Reference
Yes	1.767 (1.107–2.821)	0.017	1.123 (0.689–1.830)	0.642

Bold emphasis indicates a statistically significant p-value