Table 3.

Univariate and multivariate analysis of prognostic factors for overall survival in CRC patients

Variable	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
UTX expression
Low expression	Reference		Reference
High expression	0.615 (0.377–1.001)	0.051	0.683 (0.414–1.125)	0.134
Age
≤ 60	Reference		NA
> 60	1.233 (0.793–1.918)	0.353
Sex
Male	Reference		NA
Female	1.233 (0.793–1.918)	0.308
Tumor location
Colon	Reference		NA
Return	0.699 (0.450–1.086)	0.110
Preoperative serum CEA
Normal	Reference		Reference
Elevated	2.364 (1.501–3.722)	< 0.001	1.689 (1.060–2.694)	0.028
pT stage
T2	Reference
T3	4.245 (0.930–19.377)	0.062	3.915 (0.840–18.251)	0.082
T4	10.531 (2.579–42.994)	0.001	6.871 (1.649–28.622)	0.008
pN stage
0	Reference		Reference
1	2.858 (1.580–5.172)	0.001	0.586 (0.280–1.227)	0.156
2	4.143 (2.334–7.353)	< 0.001	0.708 (0.346–1.451)	0.346
TNM stage
I + II	Reference		Reference
III + IV	6.493 (3.240–13.011)	< 0.001	8.739 (3.227–23.667	< 0.001
Histologic type
Adenocarcinoma	Reference		NA
Mucinous adenocarcinoma	0.857 (0.314–2.344)		0.764
Grade
Well-Moderately differentiated	Reference		NA
Moderately-Poor differentiated	1.749 (0.548–5.583)		0.345
Vessel invasion
No	Reference		NA
Yes	0.990 (0.136–7.201)	0.992
Nerve invasion
No	Reference		Reference
Yes	1.573 (0.931–2.659)	0.091	0.938 (0.543–1.620)	0.818

Bold emphasis indicates a statistically significant p-value