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. 2023 Aug 24;16:1183315. doi: 10.3389/fnmol.2023.1183315

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Copyright © 2023 Siddiq, Toro, Johnson, Hansen, Xiong, Mellado, Tolentino, Johnson, Jayaraman, Suhail, Harlow, Dai, Beaumont, Sebra, Willis, Cardozo and Iyengar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene Ontology enrichment of DEGs after SCI identifies that axonogenesis is a robustly significant biological processes. Rats with and without spinal cord injury (SCI) were subjected to CAP purification for the acellular fraction for Bulk RNA-seq analysis. Lists of DEGs were used for enrichment analysis to predict differentially regulated pathways. We find the second most significant pathway to be for Axonogenesis (red box). Other pathways relevant to the CNS are demarcated with a red arrow. A complete list of Up-regulated and Down-regulated GO-pathways is shown in Supplementary Figure 1.