Table 3.

Percental change in laboratory and clinical parameters during ECAD (repeating cycles).

	Total cohort	MARS	ADVOS	SPAD	OPAL	p-value
Bilirubin [%]-change	−9.8 [−22.00 to −0.44]	−7.8 [−18.97 to −1.83]	−9.9 [−20.15 to 4.53]	−9.7 [−22.32 to −2.11]	−15.9 [−29.66 to −4.93]	0.06
Ammonia [%]-change	−7.1 [−23.83 to 13.12]	−2.1 [−22.56 to 15.63]	−8.9 [−25.57 to 8.17]	3.0 [−19.75 to 23.40]	−8.0 [−23.76 to 3.23]	0.47
Creatinine [%]-change	−12.3 [−27.47 to 2.53]	−10.7 [−23.49 to 2.70]	−13.0 [−29.23 to 0.00]	−6.8 [−16.21 to 8.99]	−22.4 [−37.39 to −3.85]	0.00
Urea [%]-change	−15.4 [−32.72 to 2.86]	−6.5 [−22.68 to 7.88]	−24.8 [−39.40 to −3.58]	−6.8 [−15.41 to 14.34]	−18.8 [−32.10 to 1.72]	0.00
Hemoglobin [%]-change	−1.4 [−7.14 to 5.99]	−2.1 [−8.43 to 2.06]	−1.8 [−7.46 to 5.88]	0.0 [−5.43 to 8.27]	0.0 [−4.84 to 6.09]	0.64
Platelet count [%]-change	−13.8 [−32.84 to 8.00]	−3.1 [−21.43 to 9.37]	−20.6 [−41.76 to 3.45]	−11.5 [−26.67 to 10.00]	−2.9 [−28.31 to 12.91]	0.99
Fibrinogen [%]-change	−6.9 [−25.45 to 3.57]	−9.2 [−17.76 to 0.00]	−10.0 [−33.33 to 6.67]	−1.2 [−9.48 to 4.44]	−7.0 [−19.88 to 0.00]	0.60
INR [%]-change	0.0 [−7.14 to 12.09]	0.0 [−2.94 to 12.91]	0.0 [−8.89 to 14.29]	0.0 [−5.00 to 8.52]	0.0 [−7.69 to 9.09]	0.63
Lactate [%]-change	3.6 [−14.90 to 30.86]	14.3 [−6.07 to 33.33]	0.0 [−18.90 to 31.01]	8.2 [−7.22 to 37.22]	−5.2 [−19.05 to 18.21]	0.42
pH [%]-change	0.3 [−0.27 to 0.75]	0.3 [−0.27 to 0.68]	0.3 [−0.40 to 0.81]	0.3 [−0.27 to 0.81]	0.3 [−0.14 to 0.67]	0.86
Base excess [%]-change	−25.7 [−80.45 to 39.29]	−21.7 [−52.42 to 36.20]	−42.2 [−111.60 to 19.17]	10.0 [−61.67 to 90.63]	−22.3 [−68.59 to 42.71]	0.07

MARS: molecular adsorbent recirculating system; ADVOS: advanced organ support system; SPAD: single pass albumin dialysis; OPAL: open albumin; INR: international normalized ratio.